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MOSINTER GROUP LIMITED
MOSINTER GROUP LIMITED

China Pimecrolimus CAS 137071-32-0 ASM 981 SDZ-ASM 981 manufacturer

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Pimecrolimus CAS 137071-32-0 ASM 981 SDZ-ASM 981 

Payment Terms: T/T,L/C,WU 
Place of Origin: Zhejiang, China (Mainland) 
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Product Detail

Model No.: MOS 14
Production Capacity: 200KG/MONTH
Delivery Date: within 7 days
CAS: 137071-32-0
Molecular Weight: 810.459
Content: 98%min
Synonyms 2: SDZ-ASM 981
density: 1.19
Means of Transport: Ocean,Land,Air
Packing: As per request of clients
Name: Pimecrolimus
Molecular Formula: C43H68ClNO11
Brand: MOSINTER
Synonyms 1: ASM 981
storage temp: -20°C

Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Elidel, SDZ-ASM-981;Inhibitors

Pimecrolimus CAS 137071-32-0 ASM 981  SDZ-ASM 981

Topical immunomodulators

Pimecrolimus is a topical immunomodulators and is a kind of semi-synthetic products of the Streptomyces-produced ascomycin. It has a greater lipophilicity than tacrolimus with a stronger affinity with the skin. It can effectively and safely control the signs and symptoms of facial seborrheic dermatitis and can quickly relieve the itching symptoms of patients with dermatitis and eczema as well as reduce the lesion area, clear atopic dermatitis (eczema) sign. Therefore, it is an effective treatment method for the treatment of atopic dermatitis (eczema) for both early remission purpose and long-term control purpose. 

Chemical Properties:White Solid

Usage: Pimecrolimus is a semi-synthetic, macrocyclic lactone derived from ascomycin by activation of the 32-hydroxy group with a triflate ester, and nucleophilic substitution with chloride under phase transfer conditions to provide the chloro analogue. Pimecrolimus has been targeted for treatment of inflammatory skin disorders. Like all tacrolimus analogues, pimecrolimus binds to receptor protein, FKBP12. The complex then binds to mTOR preventing it from interacting with target proteins. Pimecrolimus is extensively cited in the literature with over 2,000 citations.


Pimecrolimus is an immunomodulating agent of the calcineurin inhibitor class used in the treatment of atopic dermatitis (eczema).


Pimecrolimus is an ascomycin macrolactam derivative. It has been shown in vitro that pimecrolimus binds to macrophilin-12 (also referred to as FKBP-12) and inhibits calcineurin.[citation needed] Thus pimecrolimus inhibits T-cell activation by inhibiting the synthesis and release of cytokines from T-cells. Pimecrolimus also prevents the release of inflammatory cytokines and mediators from mast cells.


Pimecrolimus, like tacrolimus, belongs to the ascomycin class of macrolactam immunosuppressives, acting by the inhibition of T-cell activation by the calcineurin pathway and inhibition of the release of numerous inflammatory cytokines, thereby preventing the cascade of immune and inflammatory signals. Pimecrolimus has a similar mode of action to that of tacrolimus but is more selective, with no effect on dendritic (Langerhans) cells. It has lower permeation through the skin than topical steroids or topical tacrolimus although they have not been compared with each other for their permeation ability through mucosa. In addition, in contrast with topical steroids, pimecrolimus does not produce skin atrophy.


It has been proven to be effective in various inflammatory skin diseases, e.g., seborrheic dermatitis,cutaneous lupus erythematosus,oral lichen planus,vitiligo,and psoriasis.Tacrolimus and pimecrolimus are both calcineurin inhibitors and function as immunosuppressants.


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Company Info

MOSINTER GROUP LIMITED [China (Mainland)]

sgs ico Offline Showroom in USA

Business Type:Manufacturer, Trading Company
City: Ningbo
Province/State: Zhejiang
Country/Region: China (Mainland)

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