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MOSINTER GROUP LIMITED
MOSINTER GROUP LIMITED

China Mesna CAS 19767-45-4 2- mucofluid manufacturer

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Mesna CAS 19767-45-4 2- mucofluid 

Place of Origin: Zhejiang, China (Mainland) 
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Product Detail

Model No.: MOS7
Packing: As per request of clients
Name: Mesna
Molecular Formula: C2H5NaO3S2
Content: 98%min
Synonyms 2: mucofluid
Water Solubility: Soluble in water. Also solu...
Production Capacity: 200KG/MONTH
Delivery Date: within 7 days
CAS: 19767-45-4
Molecular Weight: 164.18
Brand: MOSINTER
Melting point: >240°C dec.

Anti-Cancer;Pharmaceutical material and intermeidates;Xanthones;All Aliphatics;Antitumors for Research and Experimental Use

Mesna CAS  19767-45-4  mucofluid

hemical PropertiesWhite to Off-White Solid
Usageadrenergic agonist, coronary vasodilator, Ca channel blocker
UsageMesna reacts with acrolein and other urotoxic metabolites of oxazaphosphorines (cyclophosphamide or ifosfamide) to form stable, non-urotoxic compounds. Mesna does not have any antitumour activity, nor does it appear to interfere with the antitumour activity of antineoplastic medicine. This medication is used to protect the bladder wall from the harmful effects of some cancer-fighting medicine.

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Mesna, sold under the brand name Mesnex among others, is a medication used in those taking cyclophosphamide or ifosfamide to decrease the risk ofbleeding from the bladder. It is used either by mouth or injection into a vein.

Common side effects include headache, vomiting, sleepiness, loss of appetite, cough, rash, and joint pain. Serious side effects include allergic reactions. Use during pregnancy appears to be safe for the baby but this use has not been well studied. Mesna is a organosulfur compound. It works by altering the breakdown products of cyclophosphamide and ifosfamide found in the urine making them less toxic.

Mesna was approved for medical use in the United States in 1988. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is about 3.50 USD per 400 mg vial. In the United Kingdom this amount costs the NHS about £3.95.


Mesna is used therapeutically to reduce the incidence of haemorrhagic cystitis and haematuria when a patient receives ifosfamide or cyclophosphamide for cancer chemotherapy. These two anticancer agents, in vivo, may be converted to urotoxic metabolites, such as acrolein.

Mesna assists to detoxify these metabolites by reaction of its sulfhydryl group with α,β-unsaturated carbonyl containing compounds such as acrolein.This reaction is known as a Michael addition. Mesna also increases urinary excretion of cysteine.


Mesna reduces the toxicity of urotoxic compounds that may form after chemotherapy administration. Mesna is a water-soluble compound with antioxidant properties, and is given concomitantly with the chemotherapeutic agents cyclophosphamide and ifosfamide. Mesna concentrates in the bladder where acroleinaccumulates after administration of chemotherapy and through a Michael addition, forms a conjugate with acrolein and other urotoxic metabolites. This conjugation reaction inactivates the urotoxic compounds to harmless metabolites. The metabolites are then excreted in the urine.

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Company Info

MOSINTER GROUP LIMITED [China (Mainland)]

sgs ico Offline Showroom in USA

Business Type:Manufacturer, Trading Company
City: Ningbo
Province/State: Zhejiang
Country/Region: China (Mainland)

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