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MOSINTER GROUP LIMITED
MOSINTER GROUP LIMITED

China TICAGRELOR CAS 274693-27-5 Unii-glh0314rvc Ticagrelor(AR-C 126532XX manufacturer

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TICAGRELOR CAS 274693-27-5 Unii-glh0314rvc Ticagrelor(AR-C 126532XX 

Payment Terms: T/T,L/C,WU 
Place of Origin: Zhejiang, China (Mainland) 
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Product Detail

Model No.: MOS4
Production Capacity: 300kg/year
Delivery Date: within 7 days
CAS: 274693-27-5
Molecular Weight: 522.574
Brand: MOSINTER
Synonyms 1: Azd 6140
Synonyms 3: Ticagrelor(AR-C 126532XX
Means of Transport: Ocean,Land,Air
Packing: As per request of clients
Name: TICAGRELOR
Molecular Formula: C23H28F2N6O4S
Content: 98%min
Density: 1.67
Synonyms 2: Unii-glh0314rvc

Icagrelor is a new kind of antiplatelet aggregation drug

TICAGRELOR CAS 274693-27-5

icagrelor is a new kind of antiplatelet aggregation drug

Medical uses

Ticagrelor is used for the prevention of thrombotic events (for example stroke or heart attack) in people with acute coronary syndrome or myocardial infarction with ST elevation. The drug is combined with acetylsalicylic acid unless the latter is contraindicated. There is no high quality evidence for the use of ticagrelor in non-ST elevation acute coronary syndrome.The FDA indication for ticagrelor is reduction of the rate of cardiovascular death, myocardial infarction (MI), and stroke in people with acute coronary syndrome or history of myocardial infarction.[citation needed]

AHA/ACC Guidelines (09/2014) state: "It is reasonable to choose ticagrelor over clopidogrel for P2Y12 inhibition treatment in patients with NSTE-ACS treated with early invasive strategy and/or coronary stenting".

Ticagrelor was found to be comparable to acetylsalicylic acid in people with acute ischemic stroke or transient ischemic attack.

Ticagrelor is a nucleoside analogue: the cyclopentane ring is similar to the sugar ribose, and the nitrogen rich aromatic ring system resembles the nucleobase purine, giving the molecule an overall similarity to adenosine. The substance has low solubility and low permeability under the Biopharmaceutics Classification System.


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packing:TICAGRELOR CAS 274693-27-5 Unii-glh0314rvc Ticagrelor(AR-C 126532XX


Contraindications for ticagrelor are: active pathological bleeding and a history of intracranial bleeding, as well as reduced liver function and combination with drugs that strongly influence activity of the liver enzyme CYP3A4, because the drug is metabolized via CYP3A4 and excreted via the liver.


The most common side effects are shortness of breath (dyspnea, 14%) and various types of bleeding, such as hematoma, nosebleed, gastrointestinal,subcutaneous or dermal bleeding. Ventricular pauses of 3 seconds occur in 5 percent of people in the first week of treatment. Ticagrelor should be administered with caution or avoided in patients with advanced sinoauricular disease. Allergic skin reactions such as rash and itching have been observed in less than 1% of patients.


Ticagrelor is a nucleoside analogue: the cyclopentane ring is similar to the sugar ribose, and the nitrogen rich aromatic ring system resembles thenucleobase purine, giving the molecule an overall similarity to adenosine. The substance has low solubility and low permeability under the Biopharmaceutics Classification System.


Like the thienopyridines prasugrel, clopidogrel and ticlopidine, ticagrelor blocks adenosine diphosphate (ADP) receptors of subtype P2Y12. In contrast to the other antiplatelet drugs, ticagrelor has a binding site different from ADP, making it an allosteric antagonist, and the blockage is reversible. Moreover, the drug does not need hepatic activation, which might work better for patients with genetic variants regarding the enzyme CYP2C19 (although it is not certain whether clopidogrel is significantly influenced by such variants).

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Company Info

MOSINTER GROUP LIMITED [China (Mainland)]

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Business Type:Manufacturer, Trading Company
City: Ningbo
Province/State: Zhejiang
Country/Region: China (Mainland)

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