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Ceritinib CAS 1032900-25-6 LDK378 Ceritinib 

Payment Terms: T/T,L/C,WU 
Place of Origin: Zhejiang, China (Mainland) 
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Product Detail

Model No.: MOS3
Production Capacity: 300kg/year
Delivery Date: within 7 days
CAS: 1032900-25-6
Molecular Weight: 558.13514
Synonyms 2: LDK378 Ceritinib
Means of Transport: Ocean,Land,Air
Packing: As per request of clients
Name: Ceritinib
Molecular Formula: C28H36ClN5O3S
Content: 98%min
Synonyms 1: LDK378
Product Categories: API;Inhibitors

Ceritinib was found at physiological concentrations to inhibit ALK, insulin-like growth factor 1 receptor (IGF-1R)

Ceritinib (INN, trade name Zykadia /zaɪˈkeɪdiːə/ zy-KAY-dee-ə) is a drug for the treatment of a specific type of lung cancer. It is an anaplastic lymphoma kinase (ALK) inhibitor.It was developed by Novartis. It was approved in April 2014 by the Food and Drug Administration for the treatment of ALK-positive metastatic non-small cell lung cancer (NSCLC) in patients that failed treatment with crizotinib. It is a more effective, but more toxic, alternative to traditional platinum-based chemotherapies.

Adverse effects

Serious adverse effects include gastrointestinal toxicity, hepatotoxicity, interstitial lung disease, prolonged QT syndrome, hyperglycemia, bradycardia, and pancreatitis. The most commonly reported side effects were diarrhea, nausea, elevated liver enzymes, vomiting, abdominal pain, fatigue, decreased appetite, and constipation.

More than half of patients in clinical trials experienced adverse events that necessitated a reduction in dose.


Ceritinib was found at physiological concentrations to inhibit ALK, insulin-like growth factor 1 receptor (IGF-1R), and ROS1.

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