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MOSINTER GROUP LIMITED
MOSINTER GROUP LIMITED

China Apramycin CAS 37321-09-8 Aprymycin manufacturer

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Apramycin CAS 37321-09-8 Aprymycin 

Payment Terms: T/T,L/C,WU 
Place of Origin: Zhejiang, China (Mainland) 
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Product Detail

Means of Transport: Ocean,Land,Air
Packing: As per request of clients
CAS: 37321-09-8
Molecular weight: 539.5771
Boiling point: 823°C at 760 mmHg
Flash point: 451.6°C
Production Capacity: 100Ton/year
Delivery Date: within 7 days
Molecular formula: C21H41N5O11
Density: 1.56g/cm3
Refractive index: 1.657
Vapour Pressur: 2.11E-31mmHg at 25°C

Apramycin (also Nebramycin II) is an aminoglycoside antibiotic used in veterinary medicine. It is produced by Streptomyces tenebrarius.

Apramycin (CAS: 37321-09-8)


Synonyms(2R,3R,4S,5S,6S)-5-amino-2-{[(2R,3S,4R,4aR,7R,8aS)-7-amino-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl]oxy}-4-hydroxy-3-(methylamino)octahydropyrano[3,2-b]pyran-2-yl]oxy}-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4-diol (non-preferred name); 5-amino-2-({7-amino-6-[(4,6-diamino-2,3-dihydroxycyclohexyl)oxy]-4-hydroxy-3-(methylamino)octahydropyrano[3,2-b]pyran-2-yl}oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4-diol (non-preferred name); Aprymycin; 3,7-trideoxy-7-(methylamino)-d-glycero-alpha-d-allo-octadialdo-1,5:8,4-dipyra
Molecular FormulaC21H41N5O11
Molecular Weight539.5771
Density1.56g/cm3
Boiling point823°C at 760 mmHg
Refractive index1.657
Flash point451.6°C
Vapour Pressur2.11E-31mmHg at 25°C
EINECS253-460-1


Apramycin (also Nebramycin II) is an aminoglycoside antibiotic used in veterinary medicine. It is produced by Streptomyces tenebrarius.


Indication

Apramycin is used for the treatment of bacterial infections in animals.


Mechanism of action

Apramycin stands out among aminoglycosides for its mechanism of action which is based on blocking translocation and its ability to bind also to the eukaryotic decoding site despite differences in key residues required for apramycin recognition by the bacterial target. The drug binds in the deep groove of the RNA which forms a continuously stacked helix comprising non-canonical C.A and G.A base pairs and a bulged-out adenine. The binding mode of apramycin at the human decoding-site RNA is distinct from aminoglycoside recognition of the bacterial target, suggesting a molecular basis for the actions of apramycin in eukaryotes and bacteria.


Spectrum of bacterial susceptibility and resistance

Apramycin can be used to treat bacterial infections in animals caused by Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. The following shows susceptibility data on medically significant organisms:


Escherichia coli - 1 μg/mL - >512 μg/mL (this large range may be due to resistant organisms, typical MIC values are likely in the range of 2 -8 μg/mL.

Klebsiella pneumoniae - 2 μg/mL - >256 μg/mL

Pseudomonas aeruginosa - 4 μg/mL


Apramycin CAS 37321-09-8 Aprymycin

Appearance: white powder

Apramycin CAS 37321-09-8 Aprymycin

Package: 25KG Drum or As per request of clients

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Company Info

MOSINTER GROUP LIMITED [China (Mainland)]

sgs ico Offline Showroom in USA

Business Type:Manufacturer, Trading Company
City: Ningbo
Province/State: Zhejiang
Country/Region: China (Mainland)

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