Offline Showroom in USA
Post Offer Free
MOSINTER GROUP LIMITED
MOSINTER GROUP LIMITED  

Gold Index: 82941

You are here: home  > Pharmaceutical Chemicals API  > Veterinary Medicine API  > Dimetridazole CAS 551-92-8 1 2-Dimethyl-5-nitroimidazole 1 2-Dimethy-5-Nitro Imidazole 1 2-dimethyl-5-nitro-1H-imidazo

Dimetridazole CAS 551-92-8 1 2-Dimethyl-5-nitroimidazole 1 2-Dimethy-5-Nitro Imidazole 1 2-dimethyl-5-nitro-1H-imidazo 

Payment Terms: T/T,L/C,WU 
Place of Origin: Zhejiang, China (Mainland) 
inquire skype
Add to My Favorites
HiSupplier Escrow
Share |

Product Detail

Means of Transport: Ocean,Land,Air
Packing: As per request of clients
CAS: 551-92-8
Molecular weight: 141.128
Refractive index: 1.598
Flash point: 143.5°C
Vapour Pressur: 0.000901mmHg at 25°C
Production Capacity: 100Ton/year
Delivery Date: within 7 days
Molecular formula: C5H7N3O2
Density: 1.36g/cm3
Melting point: 177-182℃
Boiling point: 313.7°C at 760 mmHg

Glyoxal as a starting material, acetaldehyde, ammonia cyclization to give 2-methylimidazole

Dimetridazole (CAS: 551-92-8)


Synonyms1,2-Dimethyl-5-nitroimidazole; 1,2-Dimethy-5-Nitro Imidazole; 1,2-dimethyl-5-nitro-1H-imidazole
Molecular FormulaC5H7N3O2
Molecular Weight141.128
CAS Registry Number551-92-8
EINECS209-001-2
Density1.36g/cm3
Melting point177-182℃
Boiling point313.7°C at 760 mmHg
Refractive index1.598
Flash point143.5°C
Vapour Pressur0.000901mmHg at 25°C

Molecular Structure

Dimetridazole is a drug that combats protozoan infections. It is a nitroimidazole class drug. It has been banned by the Canadian government as a livestock feed additive.


It used to be commonly added to poultry feed. This led to it being found in eggs. Because of suspicions of it being carcinogenic its use has been legally limited but it is still found in the eggs.


Pale yellow needle crystalline powder, odorless. Melting point 138-139 ℃. Soluble in chloroform, ethanol, dilute alkali co acid, insoluble in ether hydration. Hydrochloride salt was dissolved in hydrated ethanol, slightly soluble in acetone.



Production method

Glyoxal as a starting material, acetaldehyde, ammonia cyclization to give 2-methylimidazole (C4H5N2, [693--98-1]). Then nitration to give 2-methyl-5-nitro-imidazole (C4H6N3O2, [696-23-1]. Finally, dimethyl sulfate methylation obtain metronidazole imidazole Intermediate 2-methylimidazole can also be B diamine and acetonitrile cyclization to give 2-methyl imidazoline, then add the active catalytic dehydrogenation of nickel.

2-methylimidazole as raw materials, nitration, methyl ester derived.

40g of urea dissolved in 100mL water, adding 40mL of concentrated nitric acid, the resulting solution Ⅰ. Control temperature is less than 50 ℃, the 70g2- methylimidazole was slowly added 200mL industrial sulfuric acid to obtain a solution Ⅱ. The solution was slowly poured into a solution Ⅱ Ⅰ allowed to stand at room temperature for 24h, and then stirring the reaction temperature was raised to 80 ℃ 2h, the reaction temperature was raised to 110 ℃ 0.5h. Was cooled to 80 ℃ 200mL of concentrated nitric acid was added dropwise, the reaction temperature was raised to 120 ℃ stirred for 2h, and finally at below 150 ℃ excess nitric acid was distilled off. Cooling to 40 ℃, diluted with 400mL water, aqueous ammonia, PH = 3.5-4.0. Cool to room temperature, filtered, washed, and dried to give 2-methyl-5-nitroimidazole 83.8g (melting point 248-250 ℃), a yield of 77.3%.

In the three-neck flask was added 50g of the above product and 85% formic acid 60mL, heated to 80 ℃, was added dropwise dimethyl sulfate [(CH3) 2SO4] within 30min 60g, followed by reaction 0.5h. Then solvent was distilled off, water was added 50mL, distillation over an acid, and then water was added 50mL, ammonia adjust PH = 2.5. Cooled to room temperature, filtered, dried residue was not 2-methyl-5-nitro-imidazole 12.4g reaction. After the filtrate was treated with active carbon is added aqueous ammonia PH = 6-7, filtered, washed, and dried to obtain the product 29.3g (melting point 138-140 ℃), a yield of 70.3%. The total yield of 54.3%.


Dimetridazole CAS 551-92-8 1 2-Dimethyl-5-nitroimidazole 1 2-Dimethy-5-Nitro Imidazole 1 2-dimethyl-5-nitro-1H-imidazo

Appearance: Light yellow powder

Dimetridazole CAS 551-92-8 1 2-Dimethyl-5-nitroimidazole 1 2-Dimethy-5-Nitro Imidazole 1 2-dimethyl-5-nitro-1H-imidazo

Package: 25KG Drum or as per request of clients

bigPhoto
skype Mr. Fedor

Tel: +86-574-89212210
Fax: +86-574-89212215
Mobile: 86- 189 8930 5995
Contact to this supplier

Didn't find what you're looking for? Post Buying Lead or contact HiSupplier Customer Service Center  for help!

Related Search

Find more related products in following catalogs on Hisupplier.com

Company Info

MOSINTER GROUP LIMITED [China (Mainland)]

Offline Showroom in USA

Business Type:Manufacturer, Trading Company
City: Ningbo
Province/State: Zhejiang
Country/Region: China (Mainland)

Follow Us: Follow us on facebook Follow us on linkedin

Fedor:   skype

You May Like: