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nicarbazin CAS 330-95-0 Nicarbazine 

Payment Terms: T/T,L/C,WU 
Place of Origin: Zhejiang, China (Mainland) 
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Product Detail

Means of Transport: Ocean,Land,Air
Packing: As per request of clients
CAS: 330-95-0
Molecular Weight: 426.3828
Flash point: 204.7°C
Boiling point: 414.8°C at 760 mmHg
Hazard Symbols: Xi:Irritant;
Production Capacity: 100Ton/year
Delivery Date: within 7 days
Molecular Formula: C19H18N6O6
EINECS: 206-359-1
Vapour Pressur: 4.32E-07mmHg at 25°C
Risk Codes: R36/37/38:
Safety Description: S26:; S36

Nicarbazin is a coccidiostat used on meat chickens. It is also used as a contraceptive for population control of Canada geese and feral pigeons.

Nicarbazin (CAS 330-95-0)





Yellow green or yellow powder; Odorless, Slight peculiar smell

Yellow green powder; Slight peculiar smell

Melting point

Melt and resolve at 260~265℃

Melt and resolve at 264℃




Acidity or alkalinity



Residue on ignition

Not more than 0.5%



Not more concentrated than reference substance

Less concentrated than reference substance

Loss on Drying

Not more than 1.0%


Ammonium salt

Not more than 1.0%



Not more than 0.35


Assay (On the dried basis)

C13H10N4O5 67.4%~73.0%



C6H8O 27.7~30.0%


Chemical Properties

Light yellow crystalline powder, no foul. Mp 265-275 ℃ (decomposition). Non-hygroscopic, insoluble in water, ethanol, chloroform and ether, slightly soluble in dimethylformamide. Grinding and water will slowly break down, decompose quickly in dilute acid.


The product of chicken cecal coccidiosis and stack-shaped Eimeria, Eimeria tenella, Eimeria poison, Bordetella Eimeria have a good preventive effect. With high efficiency, low toxicity, stable performance, the advantages of small resistance. It can be used with coccidia ester combination better. Note: ① laying hens disabled; ② discontinued four days before slaughter; when the temperature is above 45 ℃ ③ disabled.


Anti coccidiosis medicine for the treatment of coccidiosis

Production method

1 is composed of 4,4'-nitro stilbene urea (DNC) and acetyl acetone and urea cyclization compound.

(1) DNC synthesis. Methyl amine and nitrobenzene by paranitroaniline reflux in dimethyl formamide (DMF) in the condensation, yield 85% -90%; p-nitroaniline and also by the reaction of phosgene in toluene and too, yield 96.5%; or nitrobenzene hydrochloride, in dibutyl phthalate with urea condensation heating is made.

50g nitroaniline was added 180mL of concentrated hydrochloric acid, warmed to dissolve with stirring, and reacted at reflux micro 1.5h. After cooling, the precipitated bright yellow leaf-shaped p-nitroanilide hydrochloride crystals, m.p. 173-174 ℃, 95% yield.

The hydrochloride 10.2g (0.0584mol) and 1.5g (0.025mol) of urea was added 60mL dibutyl phthalate, the reaction was stirred at 180 ℃ in 6h. Cooling to 20 ℃ filtered, washed with ethanol, water, washed with a small amount of toluene and dried to give a yellow green powder DNC, m.p. 310-314 ℃ (decomposition), yield 65%.

(2) Synthesis of nicarbazin. The 8.1g (0.027mol) DNC, 2.5g (0.042mol) urea, 4mL acetylacetone and a small amount of concentrated hydrochloric acid were added 35mL of anhydrous ethanol, the reaction mixture was stirred at reflux for 10-15h, cooled to room temperature and crystallized, isolated by centrifugation, ethanol washed, and dried to give a yellow composite powder, yield 80%

2 consists of 4,4 urea nitro stilbene (DNC) and 2-hydroxy-4,6-dimethyl-pyrimidine (HDP) at a molar ratio of 1: 1 complex. HDP prepared from acetylacetone and urea condensation reaction.

Appearance: Yellow green or yellow powder; Odorless, Slight peculiar smell

Packing: 25KG Drum or As per request of clients

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Business Type:Manufacturer, Trading Company
City: Ningbo
Province/State: Zhejiang
Country/Region: China (Mainland)

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