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Roxithromycin CAS 80214-83-1 Roxythromycin Roxithromycine 

Payment Terms: T/T,L/C,WU 
Place of Origin: Zhejiang, China (Mainland) 
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Product Detail

Means of Transport: Ocean,Land,Air
Packing: As per request of clients
CAS: 80214-83-1
Molecular weight: 837.0465
Boiling point: 864.7°C at 760 mmHg
Refractive index: 1.535
Hazard Symbols: Xn:Harmful
Production Capacity: 100Ton/year
Delivery Date: within 7 days
Molecular formula: C41H76N2O15
Density: 1.25g/cm3
Flash point: 476.7°C
Vapour Pressur: 7.17E-35mmHg at 25°C
Risk Codes: R22:Harmful if swallowed.

Roxithromycin is a semi-synthetic macrolide antibiotic. It is used to treat respiratory tract, urinary and soft tissue infections.

Roxithromycin (CAS: 80214-83-1)





White or almost white crystalline powder

white crystalline powder


Very slight soluble in water, freely soluble in acetone, in alcohol and in methylene chloride. It is slightly soluble in dilute hydrochioric acid.



1. IR: Conforms to the roxithromycin CRS spectrum

2. HPLC: Similar inretention time and size to the principal peak of the reference solution(a)


Appearance of solution

Clear and colourless(0.2/20ml methanol)


Specific optical rotation

-93°~-96°(Anhydrous substance 0.500g/50ml acetone)


Related substances

1. Impurity G≤1.0%


2. Impurity A, B, C, D, E, F, H, I, J≤0.5%


3. Total Impurities ≤ 3.0%


Heavy Metals

≤ 10 ppm

< 10 ppm


≤ 3.0%


Sulphated ash

≤ 0.1%


Resdual solvents

Methanol ≤ 3000 ppm

286 ppm

Acetone ≤ 5000 ppm

Not detected

Methylene Chloride ≤ 600 ppm

Not detected



(Anhydrous substance)


Roxithromycin is a semi-synthetic macrolide antibiotic. It is used to treat respiratory tract, urinary and soft tissue infections. Roxithromycin is derived from erythromycin, containing the same 14-membered lactone ring. However, an N-oxime side chain is attached to the lactone ring. It is also currently undergoing clinical trials for the treatment of male-pattern hair loss.

Roxithromycin is available under several brandnames. Roxithromycin is not available in the United States. Roxithromycin is available in Australia. Roxithromycin has also been tested to possess antimalarial activity.

Available forms

Roxithromycin is commonly available as tablets or oral suspension.

Mechanism of action

Roxithromycin prevents bacteria from growing, by interfering with their protein synthesis. Roxithromycin binds to the subunit 50S of the bacterial ribosome, and thus inhibits the translocation of peptides. Roxithromycin has similar antimicrobial spectrum as erythromycin, but is more effective against certain gram-negative bacteria, particularly Legionella pneumophila.


When taken before a meal, roxithromycin is very rapidly absorbed, and diffused into most tissues and phagocytes. Due to the high concentration in phagocytes, roxithromycin is actively transported to the site of infection. During active phagocytosis, large concentrations of roxithromycin are released.


Only a small portion of roxithromycin is metabolised. Most of roxithromycin is secreted unchanged into the bile and some in expired air. Under 10% is excreted into the urine. Roxithromycin's half-life is 12 hours.

Side effects

Most common side effects are gastrointestinal; diarrhoea, nausea, abdominal pain and vomiting. Less common side effects include central or peripheral nervous system events such as headaches, dizziness, vertigo, and also the rarely seen rashes, abnormal liver function values and alteration in senses of smell and taste.

Drug interactions

Roxithromycin has fewer interactions than erythromycin as it has a lower affinity for cytochrome P450.

Roxithromycin does not interact with hormonal contraceptives, prednisolone, carbamazepine, ranitidine or antacids.

When roxithromycin is administered with theophylline, some studies have shown an increase in the plasma concentration of theophylline. A change in dosage is usually not required but patients with high levels of theophylline at the start of the treatment should have their plasma levels monitored.

Roxithromycin appears to interact with warfarin. This is shown by an increase in prothrombin time (international normalised ratio) in patients taking roxithromycin and warfarin concurrently. As a consequence, severe bleeding episodes have occurred.

Appearance: White or almost white crystalline powder

Package: 25 KG/Drum or As per request of clients

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Business Type:Manufacturer, Trading Company
City: Ningbo
Province/State: Zhejiang
Country/Region: China (Mainland)

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