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Hydrazinecarboxylic acid 2- 4- 2-pyridinyl phenyl methyl- 1 1-dimethylethyl este CAS 198904-85-7 Atazanavir intermediate 

Payment Terms: T/T,L/C,WU 
Place of Origin: Zhejiang, China (Mainland) 
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Product Detail

Means of Transport: Ocean,Land,Air
Packing: According to the request of...
Brand: MOSINTER
Density: 1.117g/cm3
Molecular formula: C17H21N3O2
Production Capacity: 100Ton/Year
Delivery Date: Within 7 days
CAS: 198904-85-7
Molecular weight: 299.3675
Refractive index: 1.555

Hydrazinecarboxylic acid 2-[[4-(2-pyridinyl)phenyl]methyl]-, 1,1-dimethylethyl ester
(CAS: 198904-85-7) is an intermediate of atazanavir.

Hydrazinecarboxylic acid 2-[[4-(2-pyridinyl)phenyl]methyl]-, 1,1-dimethylethyl ester

(CAS: 198904-85-7) is an intermediate of atazanavir.


Attribute

Molecular Formula

C17H21N3O2

Molecular Weight

299.3675

Density

1.117g/cm3

Refractive index

1.555

Molecular Formula


Synonyms: tert-Butyl 2-(4-(pyridin-2-yl)benzyl)hydrazinecarboxylate; N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridin-2-yl)benzyl]hydrazine; T-butyl-2-[4-(pyridin-2-yl)benzyl] hydrazinecarboxylate; Hydrazinecarboxylic acid; 2-[[4-(2-pyridinyl)phenyl]methyl]-, 1,1-dimethylethyl ester; T-butyl-2-[4-(pyridin-2-yl)benzyl] hydrazine carboxylate; Hydrazinecarboxylicacid,2-[[4-(2-pyridinyl)phenyl]methyl]-,1,1-dimethylethylester; N-1-(tert-Butoxycarbonyl)-N-2-[4-(pyridin-2-yl)benzyl]-hydrazine; Hydrazinecarboxylic acid,2-[[4-(2-pyridinyl)phenyl]methyl]-,1,1-dimethylethyl ester; T-butyl-2-4-(pyridin-2-yl)benzyl hydrazine carboxylate; 2-[[4-(2-Pyridinyl)phenyl]methyl]-hydrazinecarboxylic acid 1,1-dimethylethyl ester; t-butyl-2-(4-(pyridine-2-yl)benzyl)hydrazinecarboxylate; tert-Butyl,2-(4-(pyridin-2-yl)benzyl)hydrazinecarboxylate; Hydrazinecarboxylic acid 2-[[4-(2-pyridinyl)phenyl]methyl]-,1,1-dimethylethyl ester


Atazanavir is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV).

 

Atazanavir is distinguished from other PIs in that it can be given once-daily (rather than requiring multiple doses per day) and has lesser effects on the patient's lipid profile (the amounts of cholesterol and other fatty substances in the blood). Like other protease inhibitors, it is used only in combination with other HIV medications.

 

Atazanavir is the first PI approved for once-daily dosing, and also appears to be less likely to cause lipodystrophy and elevated cholesterol as side effects. It may also not be cross-resistant with other PIs. When boosted with ritonavir it is equivalent in potency to lopinavir for use in salvage therapy in patients with a degree of drug resistance, although boosting with ritonavir reduces the metabolic advantages of atazanavir.

 

Medical uses

Atazanavir is used in the treatment of HIV. The efficacy of atazanavir has been assessed in a number of well designed trials in ART-naive and ART-experienced adults.

 

Adverse effects

Bilirubin levels in the blood are normally asymptomatically raised with atazanavir. A single case of torsades de pointes attributable to atazanavir therapy has been described. Atazanavir has less effect on glucose levels than ritonavir.

 

Contraindications

Atazanavir should not be used with proton-pump inhibitors, such as omeprazole (Prilosec), esomeprazole (Nexium), or rabeprazole (Aciphex).  "A 76% reduction in atazanavir area under the concentration-time curve (AUC) and a 78% reduction in atazanavir trough plasma concentration (Cmin) were observed when Reyataz/ritonavir [another protease inhibitor, often prescribed with azatanavir] 300/100 mg was coadministered with omeprazole 40 mg." In other words, proton pump inhibitors reduce the absorption and effects of atazanavir due to their effect in decreasing stomach acidity.

 

Appearance: Fine powder

Packing: 25KG drum

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Company Info

MOSINTER GROUP LIMITED [China (Mainland)]

Offline Showroom in USA

Business Type:Manufacturer, Trading Company
City: Ningbo
Province/State: Zhejiang
Country/Region: China (Mainland)

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