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D-cycloserine CAS 68-41-7 D-4-Amino-3-isoxazolidinone 

Payment Terms: T/T,L/C,WU 
Place of Origin: Zhejiang, China (Mainland) 
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Product Detail

Means of Transport: Ocean,Land,Air
Packing: According to the request of...
Brand Name: MOSINTER
Product Name: D-cycloserine
Melting point: 147℃
Water solubility: SOLUBLE
EINECS: 200-688-4
Production Capacity: 50 Kilogram/Year
Delivery Date: within 7 days
CAS No.: 68-41-7
Molecular Formul: C3H7N2O2
CAS NO.: 68-41-7
Molecular Weight: 103.0993

It is a colorless solid that is produced by some bacteria. It is an antibiotic effective against Mycobacterium tuberculosis.

D-Cycloserine (CAS: 68-41-7) is an amino acid with an unusual structure.


D-Cycloserine Attribute

Molecular Formula

C3H7N2O2

Molecular Weight

103.0993

Melting point

147℃

Water solubility

SOLUBLE

D-Cycloserine Molecular Formula


Synonyms: Cycloserine; D-Cycloserine, STREPTOMYCES ORCHIDACEUS ; D-4-Amino-3-isoxazolidinone; (R)-(+)-CYCLOSERINE; (R)-4-AMINO-ISOXAZOLIDIN-3-ONE; (R)-4-AMINO-3-ISOXAZOLIDINONE ; R(+)-4-AMINO-3-ISOXAZOLIDINONE; (R)-4-AMINO-3-ISOXAZOLIDONE; SEROMYCIN; ORIENTOMYCIN; (4R)-4-amino-1,2-oxazolidin-3-one; (4R)-3-oxoisoxazolidin-4-aminium; D-Cyloserine


It is a colorless solid that is produced by some bacteria. It is an antibiotic effective against Mycobacterium tuberculosis. Since the discovery that cycloserine is able to penetrate into the central nervous system, numerous studies have been conducted to assess the efficacy of cycloserine for psychiatric disorders. It has been found to be effective in the treatment of some neurological disorders, due to its effect as a selective partial agonist of the N-methyl-D-aspartic acid (NMDA) glutamatergic receptors found in the basolateral nucleus of the amygdala. Specifically, cycloserine affects the glycine-binding sites which are important for opening these NMDA channels. Cycloserine is stable under basic conditions, with the greatest stability at pH = 11.5.

 

D- cycloserine is a lavendulae produced by Streptomyces (Streptomyces lavendulae) and orchids Streptomyces (S.orchidaceus) or synthesized by chemical peptide broad-spectrum antibiotics. A broad spectrum antibiotic cycloserine, except tuberculosis, the most positive and Gram-negative bacteria, rickettsia and some protozoa, also have inhibitory effect on streptomycin, viomycin of aminosalicylates acid-resistant Mycobacterium tuberculosis, isoniazid, pyrazinamide, also play a role. Cycloserine and isoniazid for tuberculosis H37RV synergy mild, and streptomycin neither synergy nor antagonism displayed. This product antibacterial agents, increasing the dose or prolong the duration of action of bacteria, does not appear sterilization.

 

Mechanism D- cycloserine antibacterial effect is to inhibit the biosynthesis of cell wall peptidoglycan, because it is a structural analog of D- alanine, D- alanine can be inhibited competitively with peptidoglycan synthesis process Two important enzymes - alanine racemase and D- alanyl -D- alanine synthetase. Its Mycobacterium tuberculosis (Mycobacterium tuberculosis) is weak, streptomycin only 1 / 10-1 / 20. The advantages of drug-resistant strains of bacteria are effective, and less resistance to it. It can be used in combination with other anti-tuberculosis medicine in the treatment of tuberculosis resistant Mycobacterium tuberculosis caused.

 

Cycloserine is the second-line medicine, can inhibit the growth of Mycobacterium tuberculosis, but the effect is relatively weak first-line medicine, the efficacy of TB is low, alone can produce resistance, but resistance occurs slowly than other anti-TB medicine, among other anti-TB medicine and no cross-resistance. Antibacterial mechanism of action is to inhibit the synthesis of bacterial cell wall peptidoglycan of cell wall so that the defect. The main structural component of the bacterial cell wall is the cell wall peptidoglycan, the N- acetylglucosamine (GNAc) and N- and five peptides linked acetylmuramic acid (MNAc) repeat alternately linked together. Formed cytoplasmic peptidoglycan precursor may be hampered cycloserine cycloserine inhibit racemase and D- alanine synthetase can hinder the formation of acid N- acetylmuramic five peptides.


Appearance: White crystalline powder

Packing: 25KG drum

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Company Info

MOSINTER GROUP LIMITED [China (Mainland)]

Offline Showroom in USA

Business Type:Manufacturer, Trading Company
City: Ningbo
Province/State: Zhejiang
Country/Region: China (Mainland)

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