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Rifabutin CAS 72559-06-9 RIFABUTINE 

Payment Terms: T/T,L/C,WU 
Place of Origin: Zhejiang, China (Mainland) 
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Product Detail

Means of Transport: Ocean,Land,Air
Packing: According to the request of...
Brand Name: MOSINTER
Product Name: Rifabutin
Molecular Weight: 847.0047
Refractive index: 1.623
Density: 1.339g/cm3
Production Capacity: 50 Kilogram/Year
Delivery Date: within 7 days
CAS No.: 72559-06-9
Molecular Formul: C46H62N4O11
Boiling point: 969.589°C at 760 mmHg
Flash point: 540.188°C
Vapour Pressur: 0mmHg at 25°C

It has also found to be useful in the treatment of (Chlamydia) Chlamydophila pneumoniae (Cpn) Infection.

Rifabutin (CAS: 72559-06-9) is a bactericidal antibiotic


Rifabutin Attribute

Molecular Formula

C18H20O4N3F

Molecular Weight

361.3675

Density

1.48g/cm3

Melting point

218℃

Boiling point

571.5°C at 760 mmHg

Refractive index

1.669

Flash point

299.4°C

Vapour Pressur

6.7E-14mmHg at 25°C



Rifabutin Molecular Formula



Rifabutin (Rfb) is a bactericidal antibiotic medicine primarily used in the treatment of tuberculosis. The medicine is a semi-synthetic derivative of rifamycin S. Its effect is based on blocking the DNA-dependent RNA-polymerase of the bacteria. It is effective against Gram-positive and some Gram-negative bacteria, but also against the highly resistant mycobacteria, e.g. Mycobacterium tuberculosis, M. leprae, and M. avium intracellulare.

 

Medical uses

Rifabutin is now recommended as first-line treatment for tuberculosis, but Rifampicin is more widely used because of its cheaper cost.

 

Rifabutin is used in the treatment of mycobacterium avium complex disease, a bacterial infection most commonly encountered in late-stage AIDS patients. Its main usefulness lies in the fact that it has lesser medicine interactions than rifampicin; therefore HIV infected patients on HAART are usually given rifabutin for treatment of TB.

 

Rifabutin is well tolerated in patients with HIV-related tuberculosis (TB), but new findings suggest that patients with low CD4 cell counts have a high risk of treatment failure or relapse due to acquired rifamycin resistance. Since patients co-infected with TB and HIV / AIDS are likely to get TB treated first, when the CD4 is suppressed at the time TB treatment begins, doctors and patients should be aware of a possible rifamycin resistance.

 

Rifabutin is also being investigated in trials for treating Crohn's Disease as part of the anti-MAP therapy. In a Phase 3 study administering sub-therapeutic doses of Rifabutin in combination therapy to patients not identified with MAP infections, it was associated with significant short term benefits.

 

It has also found to be useful in the treatment of (Chlamydia) Chlamydophila pneumoniae (Cpn) Infection.


Appearance: Fuchsia crystalline powder

Packing: 25KG drum

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Company Info

MOSINTER GROUP LIMITED [China (Mainland)]

Offline Showroom in USA

Business Type:Manufacturer, Trading Company
City: Ningbo
Province/State: Zhejiang
Country/Region: China (Mainland)

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