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MOSINTER GROUP LIMITED
MOSINTER GROUP LIMITED

China Pemetrexed disodium hepthydrate CAS 357166-29-1 manufacturer

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Pemetrexed disodium hepthydrate CAS 357166-29-1 

Payment Terms: T/T,WU 
Place of Origin: Zhejiang, China (Mainland) 
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Product Detail

Model No.: MOSINTER
Production Capacity: 1MT/Month
Delivery Date: with 7 days
CAS: 357166-29-1
Molecular Weight: 489.38958
Application: antitumor drug
Means of Transport: Land,Air
Packing: According to the customer r...
Name: Pemetrexed Disodium
Molecular formula: C20H19N5Na2O6.7(H2O)
Alias: N-[4-[2-(2-amino-4 7-dihydr...
Appearance: white to light yellow powde...

Pemetrexed Disodium (CAS: 357166-29-1) is a chemotherapy drug.
Its indications are the treatment of pleural mesothelioma and non-small cell lung ca

Pemetrexed Disodium (CAS: 357166-29-1) is a chemotherapy drug. 


Application: antitumor drug

Detail:

Pemetrexed disodium ;N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt
Molecular formular C20H19N5Na2O6.7(H2O)
Molecular weight597.49
CAS No.357166-30-4


Pemetrexed disodium ;N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt
Molecular formular 2(C20H19N5Na2O6).5(H2O)
Molecular weight1032.84
CAS No.357166-29-1

 Its indications are the treatment of pleural mesothelioma and non-small cell lung cancer.


Mechanism of action

Pemetrexed is chemically similar to folic acid and is in the class of chemotherapy drugs called folate antimetabolites. It works by inhibiting three enzymes used in purine and pyrimidine synthesis—thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT). By inhibiting the formation of precursor purine and pyrimidine nucleotides, pemetrexed prevents the formation of DNA and RNA, which are required for the growth and survival of both normal cells and cancer cells.


Carboplatin

Pemetrexed is also recommended in combination with carboplatin for the first-line treatment of advanced non-small cell lung cancer. However, the relative efficacy or toxicity of pemetrexed-cisplatin versus pemetrexed-carboplatin has not been established beyond what is generally thought about cisplatin or carboplatin doublet drug therapy


Supplementation

Patients should take folic acid and vitamin B12 supplement even if levels are normal when they are on pemetrexed therapy. (In clinical trials for mesothelioma, folic acid and B12 supplementation reduced the frequency of adverse events.) It is also recommended for patients to be on a steroid (e.g., dexamethasone 4 mg twice daily) on the day prior, day of, and day after Pemetrexed infusion to avoid skin rashes.


Side effects

Pemetrexed, whether used alone or in combination with cisplatin, has these side effects:

Low blood cell counts, as measured by a complete blood count. This is a dose-limiting toxicity.

Mental fatigue and sleepiness. Fatigure can be reduced through an off-label prescription of Provigil.

Nausea and vomiting. Pemetrexed's emetogenic effects are managed with prophylactic antiemetics.

Diarrhea

Oral mucositis (mouth, throat, or lip sores). Oral ulcers can be mitigated by proper oral hygiene, including rinsing of the mouth with salt water following consumption of food or drink.

Loss of appetite

Skin rash. Physician-prescribed steroids administered on the day prior, day of, and day after infusion typically avoid skin rashes.

Constipation

Appearance: white to light yellow powder

Packing: 25KG drum

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Company Info

MOSINTER GROUP LIMITED [China (Mainland)]

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Business Type:Manufacturer, Trading Company
City: Ningbo
Province/State: Zhejiang
Country/Region: China (Mainland)

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