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MOSINTER GROUP LIMITED
MOSINTER GROUP LIMITED

China Dactinomycin CAS 50-76-0 Actinomycin D manufacturer

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Dactinomycin CAS 50-76-0 Actinomycin D 

Payment Terms: T/T,L/C,WU 
Place of Origin: Zhejiang, China (Mainland) 
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Product Detail

Model No.: C62H86N12O16
Production Capacity: 6 Kilogram/Year
Delivery Date: within 7 days
Molecular Formul: C62H86N12O16
CAS NO.: 50-76-0
Storage temp.: 2-8°C
Mp: 251-253°C
Means of Transport: Ocean,Land,Air
Packing: According to the request of...
Brand: MOSINTER
Molecular Weight: 1255.417
Assay: ≥95%
EINECS: 200-063-6
Color: red powder

Dactinomycin is an antineoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA

Dactinomycin (CAS: 50-76-0)


Molecular Formul: 

C62H86N12O16

Molecular Weight: 

1255.417

CAS Registry Number: 

50-76-0

EINECS: 

200-063-6

Assay: 

≥95%

Mp: 

251-253°C

storage temp.: 

2-8°C

Color: 

red, powder

Suitability: suitable for cell culture

Stability: Stable, but light sensitive, especially in dilute solution. Incompatible with strong acids, strong bases, strong oxidizing agents. Combustible.


Dactinomycin is an antineoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymerase which interferes with DNA-dependent RNA synthesis. Induces apoptosis. Potent antitumor agent.

 

Mechanism

In cell biology, Actinomycin D is shown to have the ability to inhibit transcription. Actinomycin D does this by binding DNA at the transcription initiation complex and preventing elongation of RNA chain by RNA polymerase.

 

Clinical use

Actinomycin is a clear, yellow liquid administered intravenously and most commonly used in treatment of  a variety of cancers, including:

①Gestational trophoblastic neoplasia

②Wilms' tumor

③Rhabdomyosarcoma

④Ewing's sarcoma

⑤Malignant hydatidiform mole

Sometimes it will be combined with other medicine in Chemotherapy regimens, like the VAC regimen (with Vincristine and Cyclophosphamide) for treating rhabdomyosarcoma and Ewing's Sarcoma.

It is also used as a radiosensitizer in adjunct to radiotherapies, since it can increase the radiosensitivity of tumor cells by inhibiting repair of sublethal radiation damage and delay the onset of the compensatory hyperplasia that occurs following irradiation.

 

Side effects

Common adverse drug reaction includes bone marrow suppression, fatigue, hair loss, mouth ulcer, loss of appetite and diarrhea. Actinomycin is a vesicant, if extravasation occurs.

 

Research use

Because Actinomycin can bind DNA duplexes, it can also interfere with DNA replication, although other chemicals such as hydroxyurea are better suited for use in the laboratory as inhibitors of DNA synthesis.

Actinomycin D and its fluorescent derivative, 7-aminoactinomycin D (7-AAD), are used as stains in microscopy and flow cytometry applications. The affinity of these stains/compounds for GC-rich regions of DNA strands makes them excellent markers for DNA. 7-AAD binds to single stranded DNA; therefore it is a useful tool in determining apoptosis and distinguishing between dead cells and live ones.

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Company Info

MOSINTER GROUP LIMITED [China (Mainland)]

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Business Type:Manufacturer, Trading Company
City: Ningbo
Province/State: Zhejiang
Country/Region: China (Mainland)

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