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MOSINTER GROUP LIMITED
MOSINTER GROUP LIMITED

China Buserelin CAS 57982-77-1 EINECS261-061-9 manufacturer

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Buserelin CAS 57982-77-1 EINECS261-061-9 

Payment Terms: T/T,L/C,WU 
Place of Origin: Zhejiang, China (Mainland) 
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Product Detail

Model No.: C60H86N16O13
Production Capacity: 6 Kilogram/Year
Delivery Date: within 7 days
Density: 1.43g/cm3
Molecular Formul: C60H86N16O13
EINECS: 261-061-9
Means of Transport: Ocean,Land,Air
Packing: According to the request of...
Brand: MOSINTER
Molecular Weight: 1239.4242
CAS NO.: 57982-77-1
Purity: ≥95.0%

The drug's effects are dependent on the frequency and time course of administration.

Buserelin (CAS: 57982-77-1)


Molecular Formul:C60H86N16O13
Molecular Weight:1239.4242
CAS Registry Number: 57982-77-1
EINECS:261-061-9
Purity:≥95.0%


Sequence: Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-NHNH2Trifluoroacetate salt

Sequence(One Letter): Pyr-HWSYs(tBu)-LRP-NHNH2

 

Buserelin (INN) is a longer acting synthetic peptide analog of the naturally occurring gonadotropin-releasing hormone (GnRH/LHRH). Substitution of glycine in position 6 by D-serine and that of glycinamide in position 10 by ethylamide, leads to a nonapeptide with a significantly enhanced LHRH effect. The effects of buserelin on follicle-stimulating hormone (FSH) and luteinizing hormone (LH) release are approximately 20 to 170 times higher than those of natural LHRH.


Drug's effects

The drug's effects are dependent on the frequency and time course of administration. GnRH is released in a pulsatile fashion in the postpubertal adult. Initial interaction of any GnRH agonist, such as buserelin, with the GnRH receptor induces release of FSH and LH by gonadotrophes. Long-term exposure to constant levels of buserelin, rather than endogenous pulses, leads to downregulation of the GnRH receptors and subsequent suppression of the pituitary release of LH and FSH.

Like other GnRH agonists, buserelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, estrogen-dependent conditions (such as endometriosis or uterine fibroids), and in assisted reproduction.


Absorb

It is normally delivered via a nasal spray, but is also available as an injection.

Buserelin is water soluble and readily absorbed after subcutaneous injection (70% bioavailable). When administered correctly via the nasal route, it may be absorbed in the nasal mucosa to achieve sufficient plasma levels.


Efficacy

Clinical mainly for prostate cancer and breast cancer treatment. Treat with subcutaneous at the beginning (used with Flutamide for male), nasal spray for maintenance maintenance treatment.

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Company Info

MOSINTER GROUP LIMITED [China (Mainland)]

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Business Type:Manufacturer, Trading Company
City: Ningbo
Province/State: Zhejiang
Country/Region: China (Mainland)

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