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Celecoxib CAS 169590-42-5 Celebra 

Payment Terms: T/T,L/C,WU 
Place of Origin: Sichuan, China (Mainland) 
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Product Detail

Model No.: C17H14F3N3O2S
Production Capacity: 200Ton/Year
Delivery Date: Within 7 days
CAS: 169590-42-5
Appearance: White or pale yellow crysta...
Molecular weight: 381.37
Melting Point: 157-159°C
Alias: Celebra
Means of Transport: Ocean,Land,Air
Packing: According to the request of...
Brand: MOSINTER
Name: Celecoxib
Molecular formula: C17H14F3N3O2S
Assay: 99%
Storage condition: Store at RT

Celecoxib is used for osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation, ankylosing spondylitis

Celecoxib (CAS: 169590-42-5)

Celecoxib INN (/sɛlɨˈkɒksɪb/ se-lə-kok-sib) is a COX-2 selective nonsteroidal anti-inflammatory drug (NSAID). It is used to treat the signs and symptoms of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute pain in adults, painful menstruation, and juvenile rheumatoid arthritis in patients two years or older.

Side effects include a 37% increase in incidence of major vascular events, which include nonfatal myocardial infarction, nonfatal stroke, or death from a blood vessel-related cause. Additionally, an 81% increase in incidence of upper gastrointestinal complications occurs, which include perforations, obstructions, or gastrointestinal bleeding as in all NSAIDs.

It is marketed by Pfizer under the brand names Celebrex and Celebra for arthritis and Onsenal for polyps. Celecoxib is available by prescription in capsule form.

Medical uses

Celecoxib is used for osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation, ankylosing spondylitis, and to reduce the number of colon and rectal polyps in people with familial adenomatous polyposis. It may also be used in children with juvenile rheumatoid arthritis who are older than two years of age and weigh more than 10 kg (22 lb).

For postoperative pain, it is more or less equal to ibuprofen. For pain relief, it is similar to paracetamol (acetaminophen). And in osteoarthritis acetaminophen is the first line treatment for OA.

It was originally intended to relieve pain while minimizing the gastrointestinal adverse effects seen with conventional NSAIDs. In practice, its primary use is in people who need regular and long-term pain relief; probably, no advantage exists to using celecoxib for short-term or acute pain relief over conventional NSAIDs, except in the situation where nonselective NSAIDs or aspirin cause cutaneous reactions

Mental illness

Tentative evidence indicates its use in treating a number of psychiatric disorders, including major depression, bipolar disorder, andschizophrenia.

Familial adenomatous polyposis

It has been used to reduce colon and rectal polyps in people with familial adenomatous polyposis, but it is not known if it decreases rates of cancer,so it is not a good choice for this reason.

Adverse effects

  • Cardiovascular events: NSAIDs are associated with an increased risk of serious (and potentially fatal) adverse cardiovascular thrombotic events, including myocardial infarction and stroke. Risk may be increased with duration of use or pre-existing cardiovascular risk factors or disease.Individual cardiovascular risk profiles should be evaluated prior to prescribing. New-onset hypertension or exacerbation of hypertension may occur (NSAIDs may impair response to thiazide or loop diuretics), and may contribute to cardiovascular events; monitor blood pressure and use with caution in patients with hypertension. May cause sodium and fluid retention, use with caution in patients with edema or heart failure. Long-term cardiovascular risk in children has not been evaluated. Use the lowest effective dose for the shortest duration of time, consistent with individual patient goals, to reduce risk of cardiovascular events; alternate therapies should be considered for patients at high risk.

  • Gastrointestinal events: NSAIDs may increase risk of serious gastrointestinal (GI) ulceration, bleeding, and perforation (may be fatal). These events may occur at any time during therapy and without warning. Use caution with a history of GI disease (bleeding or ulcers), concurrent therapy with aspirin, anticoagulants and/or corticosteroids, smoking, use of alcohol, the elderly or debilitated patients. Use the lowest effective dose for the shortest duration of time, consistent with individual patient goals, to reduce risk of GI adverse events; alternate therapies should be considered for patients at high risk. When used concomitantly with ≤325 mg of aspirin, a substantial increase in the risk of gastrointestinal complications (e.g., ulcer) occurs; concomitant gastroprotective therapy (e.g., proton pump inhibitors) is recommended.

  • Hematologic effects: Anemia may occur; monitor hemoglobin or hematocrit in people on long-term treatment. Celecoxib does not usually affect PT, PTT or platelet counts; it does not inhibit platelet aggregation at approved doses.

  • People with prior history of ulcer disease or GI bleeding require special precaution. Moderate to severe hepatic impairment or GI toxicity can occur with or without warning symptoms in people treated with NSAIDs.

Celecoxib  CAS: 169590-42-5  Celebra

Celecoxib  CAS: 169590-42-5  Celebra

Celecoxib  CAS: 169590-42-5  Celebra

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MOSINTER GROUP LIMITED [China (Mainland)]

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Business Type:Manufacturer, Trading Company
City: Ningbo
Province/State: Zhejiang
Country/Region: China (Mainland)

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