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Voglibose CAS 83480-29-9 Glustat 

Payment Terms: T/T,L/C,WU 
Place of Origin: Sichuan, China (Mainland) 
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Product Detail

Model No.: C10H21NO7
Production Capacity: 200Ton/Year
Delivery Date: Within 7 days
CAS: 83480-29-9
Appearance: white powder
Assay: ≥99%
Melting Point: 162-163°C
Alias: Basen
Means of Transport: Ocean,Land,Air
Packing: According to the request of...
Name: Voglibose
Molecular formula: C10H21NO7
Molecular weight: 267.28
Storage condition: Store at -20°C

Used in the treatment of diabetes

Voglibose (CAS: 83480-29-9)

Voglibose is an oral fall blood sugar medicine, can improve postprandial hyperglycemia and diabetes by takeda Japanese company successfully developed, belongs to the alpha glycosidase inhibitor (carbohydrates to delay intestinal drug absorption and achieves hypoglycemic effect), the mechanism of action is in intestine inhibits the disaccharides broken down into simple sugars disaccharides class hydrolase (alpha glycosidase enzymes), and thus delay the digestion and absorption of sugar, so as to improve the postprandial hyperglycemia. Health adults give sugar determination of load after exhaled hydrogen, the results confirmed that the dosage of this drug in clinical under has inhibitory effect on blood glucose increased. Normal rat oral medicine, this product after the inhibition of starch and sucrose, maltose load increased blood sugar, lactose and glucose, fructose and to Portugal after load increased blood sugar without inhibition. In vitro test mechanism, according to a study for the maltase from swine and rat small intestine and sucrase, this inhibitory effect is stronger; On the other hand, the pigs and rats alpha inhibition of pancreatic amylase.

Side effect

Oral medications side effects occur mechanism is generally after the sugar into the large intestine, which are not absorbed in under the action of bacteria, formed by carbon dioxide, hydrogen, organic acid. At the same time, because the intestinal higher osmotic pressure and water retention, so the exhaust, abdominal distention, diarrhea. Because FuGe wave can sugar in intestine selective inhibition disaccharides hydrolase, delay the rapid digestion and absorption of carbohydrate in the upper small intestine, reduces the sugar into the large intestine, so the low incidence of adverse reactions. Known to have the following adverse reactions: 1) the digestive system: diarrhea, soft, borborygmus, abdominal pain, constipation, loss of appetite, nausea, vomiting, heartburn incidence (0.1 ~ 5%), stomatitis, thirst, taste abnormalities, intestinal wall sac pneumatosis disease (below 0.1%) 2) allergies, skin rashes, itching, light sensitive incidence (under 0.1%) 3) of the liver: GOT, GPT and LDH, gamma - GTP, ALP made up incidence (under 0.1%) 4) the spirit of the nervous system: headache, dizziness, staggering, sleepiness

Application: Used in the treatment of diabetes

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Business Type:Manufacturer, Trading Company
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