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You are here: home  > Other Chemical Products  > Desmopressin acetate CAS 16789-98-3 3-MERCAPTOPROPIONYL-TYR-PHE-GLN-ASN-CYS-PRO-D-ARG-GLY-NH2 ACETATE SALT


Payment Terms: T/T,L/C,WU 
Place of Origin: Sichuan, China (Mainland) 
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Product Detail

Model No.: C48H68N14O14S2
Production Capacity: 10Tons/year
Delivery Date: within 7 days
CAS: 16789-98-3
Molecular formula: C48H68N14O14S2
Molecular weight: 1129.27
Means of Transport: Ocean,Land,Air
Packing: According to the request of...
Name: Desmopressin acetate
Storage condition: -20°C

Control hemorrhage or to prevent bleeding before invasive surgery: 0.3 ug/kg body weight, subcutaneous drug or diluted with normal saline to 50-100 ml

Desmopressin acetate (CAS: 16789-98-3)


central diabetes insipidus, nocturnal enuresis and hemophilia, also used for kidney urine concentration function test. Also used for postoperative bleeding.

Dosage and administration:

Control hemorrhage or to prevent bleeding before invasive surgery: 0.3 ug/kg body weight, subcutaneous drug or diluted with normal saline to 50-100 ml, intravenous drip in 15 to 30 minutes. If curative effect is positive, can according to the initial dose of 6 to 12 hours repeat dosing 1-2 times, further repeat dosing may be less effective. Hemophiliac VIII: C concentration reaches expected value according to the principle of the same as the use factor VIII concentrate to estimate, during the medication should be conducted on a regular basis VIII: the concentration of C tracking monitoring, because of some leap, repeated to lower after the drug efficacy against nanchang. If intravenous drip annotated medicine didn't make VIII in plasma; C concentration reaches the expected increase, should add with factor VIII concentrate for treatment. For the treatment of patients with hemophilia, should refer to the coagulation test results for each patient to determine treatment plan.

Pharmacologic action:

The natural essence of desmopressin acetate ammonia salt structure analogues of vasopressin, is the chemical structure of natural hormones to make two changes, namely 1 - cysteine amino and 8 - D - arginine instead of 8 - L - arginine. Intravenous or subcutaneous desmopressin acetate for a 0.3 ug/kg body weight, can make the plasma coagulation factor vIII (vIII: C) the vitality of 2 to 4 times; Also make the Von Willebrand factor (VWF: AG) antigen, increased levels of but strong and smaller. At the same time, the release of the tissue fibrin dissolve enzyme activation factor (t - PA). Bioavailability of subcutaneous injection of about 85% of the intravenous bioavailability, according to the weight of 0.3 ug/kg dosing of blood drug concentration in the largest peak, about 60 minutes after the treatment, the average is about 600 pg/ml, plasma half-life of 3-4 hours, hemostatic effect depends on the plasma in the VIII: C, the half-life of, about 8 to 12 hours. Deoxidation vasopressin can make due to uremia, liver cirrhosis, congenital or patients with drug-induced platelet dysfunction, and the bleeding time of unknown etiology

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