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MOSINTER GROUP LIMITED
MOSINTER GROUP LIMITED

China Mubritinib CAS 366017-09-6 Mubritinib TAK 165 manufacturer

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Mubritinib CAS 366017-09-6 Mubritinib TAK 165 

Payment Terms: T/T,L/C,WU 
Place of Origin: Shandong, China (Mainland) 
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Product Detail

Model No.: C25H23F3N4O2
Production Capacity: 3.5KG/Year
Delivery Date: within 7 days
Formula: C25H23F3N4O2
Boiling point: 620.9°C at 760 mmHg
Flash(ing) point: 329.3°C
Means of Transport: Ocean,Land,Air
Packing: According to the customer r...
Brand: MOSINTER
Mol. mass: 468.47 g/mol
Density: 1.25g/cm3
Vapour pressure: 2.43E-15mmHg at 25°C

Mubritinib (TAK-165) is a protein kinase inhibitor which was under development by Takeda for the treatment of cancer.

Mubritinib (CAS: 366017-09-6)


Item

Index

Molecular Formula

C25H23F3N4O2

Molecular Weight

468.47

Specification

CP/USP/EP

Content

98%min


Mubritinib (TAK-165)  is a potent Neu (HER2) and Cdc2 p34 inhibitor with IC50 of 6 nM and 0.2μM, respectively. TAK 165 also inhibits p33cdk2 and p33cdk5. TAK 165 displays > 4000-fold selectivity over EGFR, FGFR, PDGFR, JAK1 and Src. TAK 165 exhibits potent antiproliferative effects in Neu-overexpressing cancer cell lines (IC50 = 5 nM in BT474 breast cancer cells) and significantly inhibits bladder, breast and prostate cancer xenograft growth. 

Basic Information

Mubritinib (TAK-165) is a protein kinase inhibitor which was under development by Takeda for the treatment of cancer. It completed phase Iclinical trials but appears to have been discontinued, as no new information on the drug has surfaced since December 2008.

Synthesis

Mubritinib Anti-tumor (CAS: 366017-09-6) Mubritinib; Mubritinib(TAK 165)




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Company Info

MOSINTER GROUP LIMITED [China (Mainland)]

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Business Type:Manufacturer, Trading Company
City: Ningbo
Province/State: Zhejiang
Country/Region: China (Mainland)

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