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MOSINTER GROUP LIMITED
MOSINTER GROUP LIMITED

China Doramapimod CAS 285983-48-4 Doramapimod DoraMapin BIBR796 manufacturer

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Doramapimod CAS 285983-48-4 Doramapimod DoraMapin BIBR796 

Payment Terms: T/T,L/C,WU 
Place of Origin: Shandong, China (Mainland) 
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Product Detail

Means of Transport: Ocean,Land,Air
Packing: According to the request of...
Brand: MOSINTER
Molecular weight: 527.66
Density: 1.2g/cm3
Vapour pressure: 7.36E-16mmHg at 25°C
Production Capacity: 5 KG/Year
Delivery Date: within 7 days
Molecular formula: C31H37N5O3
Boiling point: 631.6°C at 760 mmHg
Flashing point: 335.8°C

Doramapimod is a pyrazole-based allosteric inhibitor of p38 MAP Kinase

Doramapimod(CAS: 285983-48-4)


Item

Index

Molecular Formula

C31H37N5O3

Molecular Weight

527.66

Specification

CP/USP/EP

Content

98%


BIRB796 (Doramapimod) is a pyrazole-based allosteric inhibitor of p38 MAP Kinase with a Kd of 0.1 nM. BIRB796 has slow binding kinetics, as evidenced by an marked increase in apparent IC50 after preincubation periods up to 2h, as well as dissociation rates of up to six orders of magnitude greater when compared to other MAPK inhibitors. BIRB796 possesses an excellent selectivity profile over a panel of relevant kinases, with the most active being inhibition of JNK2a2 at 100 nM (330-fold selectivity).
Related studies have shown that BIRB796 also inhibits activity and activation of SAPK3/p38g (3% remaining activity at 10 uM). At these concentrations, BIRB796 blocks stress-induced phosphorylation of scaffold protein SAP97. 

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Company Info

MOSINTER GROUP LIMITED [China (Mainland)]

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Business Type:Manufacturer, Trading Company
City: Ningbo
Province/State: Zhejiang
Country/Region: China (Mainland)

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