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MOSINTER GROUP LIMITED
MOSINTER GROUP LIMITED

China Mitoxantrone CAS 65271-80-9 Dihydroxyanthraquinone manufacturer

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Mitoxantrone CAS 65271-80-9 Dihydroxyanthraquinone 

Payment Terms: T/T,L/C,WU 
Place of Origin: Sichuan, China (Mainland) 
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Product Detail

Means of Transport: Ocean,Land,Air
Packing: According to the customer r...
Brand: MOSINTER
CAS: 65271-80-9
Production Capacity: 10000T/Year
Delivery Date: within 7 days
Formula: C22H28N4O6
Mol. mass: 444.481 g/mol

Mitoxantrone is an anthracenedione (not an anthracycline)antineoplastic agent.

Mitoxantrone(CAS: 65271-80-9) 


Item

Index

Molecular Formula

C22H28N4O6

Molecular Weight

444.48

Specification

CP/USP/EP

Content

98%min


Basic Information

Mitoxantrone (INN, BAN, USAN. Also known as Mitozantrone (is the generic name in Australia)) is an anthracenedione (not an anthracycline)antineoplastic agent.


Uses

It is used in the treatment of certain types of cancer, mostly metastatic breast cancer, acute myeloid leukemia, and non-Hodgkin's lymphoma. It was also shown to improve the survival of children suffering from first relapse of acute lymphoblastic leukaemia.

The combination of mitoxantrone and prednisone is approved as a second-line treatment for metastatic hormone-refractory prostate cancer. This combination has been the first line of treatment, until recently, when combination of docetaxel and prednisone has been shown to improve survival and disease-free period.

Mitoxantrone is also used to treat multiple sclerosis (MS), most notably the subset known as secondary progressive MS. Mitoxantrone will not cure multiple sclerosis, but is effective in slowing the progression of secondary progressive MS and extending the time between relapses in relapsing-remitting MS and progressive relapsing MS.


Mechanism of action

Human topoisomerase iibeta in complex with DNA and mitoxantrone. PDB entry 4g0v. Detail showing mitoxantrone (spheres) intercalated with DNA.

Mitoxantrone is a type II topoisomerase inhibitor; it disrupts DNA synthesis and DNA repair in both healthy cells and cancer cells, by intercalation. between the DNA bases.


Side effects

As other medicine in its class, mitoxantrone may cause several adverse reactions of varying severity, such as nausea,vomiting, hair loss, heart damage, and immunosuppression. Some side effects may have delayed onset. Cardiomyopathyis a particularly concerning effect as it is irreversible; regular monitoring with echocardiograms or MUGA scans is recommended for people taking mitoxantrone.

The medication carries a total lifetime dose based on body surface area.


Synthesis

Mitoxantrone can be prepared from quinizarin:

Mitoxantrone, 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl) amino)ethyl]amino]]-9,10-anthracendione, is structurally related to the antibiotic doxorubicine. It is synthesized from danthron (1,8-dihydroxyanthraquinone), which when reacted with nitric acid, and then a mixture of sodium sulfide and thiosulfate in a base, is transformed to 1,4,5,8-tetrahydroxyanthraquinone. Reacting this with 2-aminoethylaminoethanol in the presence of chloranyl (2,3,5,6-tetrachlorobenzoquinone-1,4) gives the desired mitoxantrone.

The molecular structure of the image

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Company Info

MOSINTER GROUP LIMITED [China (Mainland)]

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Business Type:Manufacturer, Trading Company
City: Ningbo
Province/State: Zhejiang
Country/Region: China (Mainland)

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