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MOSINTER GROUP LIMITED
MOSINTER GROUP LIMITED

China Pemetrexed disodium CAS 150399-23-8 ALIMTA manufacturer

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Pemetrexed disodium CAS 150399-23-8 ALIMTA 

Payment Terms: T/T,L/C,WU 
Place of Origin: Sichuan, China (Mainland) 
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Product Detail

Means of Transport: Ocean,Land,Air
Packing: According to customer requi...
Brand: MOSINTER
Molecular weight: 597.49
Production Capacity: 2500T/Year
Delivery Date: within 7 days
Content: ≥99%
Molecular Formula: C20H33N5Na2O13

Pemetrexed through transport carrier of folic acid and folic acid binding protein on the cell membrane transport system into the cell.

Pemetrexed disodium(CAS: 150399-23-8)

Item

Index

Molecular Formula

C20H19N5Na2O6

Molecular Weight

471.37

Specification

CP/USP/EP

Content

99%min


Appearance

This product is a white to light yellow or greenish yellow freeze drying solids.

Pharmacologic action

Pemetrexed through transport carrier of folic acid and folic acid binding protein on the cell membrane transport system into the cell. Once the pemetrexed enters the cells, it is in the leaves under the action of acyl glutamate synthetase more changes into the form of glutamic acid. Glutamate persist more cells become thymidylic acid synthetase and ammonia amide nucleotide formyl transferase inhibitor. More pancreatic acidification in rendering time - concentration dependence process within the tumor cells, and in normal tissues concentration is very low. More pancreatic acidic metabolites in the half-life of extended within the tumor cells, and thus prolong the effect of drug in tumor cells. Preclinical studies have shown that pemetrexed inhibits tumor cell lines in vitro (MSTO? 211 h, NCI? H2052) growth. Mesothelioma cell line MSTO? 211 h research shows pemetrexed have synergy with cisplatin plus.

Genetic toxicity
In mice bone marrow micronucleus measurement display pemetrexed is breaking agent, but several in vitro experimental study (Ames determination, determination of CHO cells) are not shown mutagenic effect.

Reproduction toxicity

Pemetrexed according to 0.1 mg/kg/day or larger doses (equivalent to 1/1666 of the recommended dose) human male mice, too little can lead to reduced fertility, semen and testicular atrophy.

Carcinogenesis

Not to pemetrexed effect that cause cancer research.




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Company Info

MOSINTER GROUP LIMITED [China (Mainland)]

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Business Type:Manufacturer, Trading Company
City: Ningbo
Province/State: Zhejiang
Country/Region: China (Mainland)

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