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MOSINTER GROUP LIMITED
MOSINTER GROUP LIMITED

China Erlotinib hydrochloride CAS 183319-69-9 ERLOTINIB HCL SALT Erlotinib HCl Tarceva Hydrochloride See E625000 manufacturer

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Erlotinib hydrochloride CAS 183319-69-9 ERLOTINIB HCL SALT Erlotinib HCl Tarceva Hydrochloride See E625000 

Payment Terms: T/T,L/C,WU 
Place of Origin: Shandong, China (Mainland) 
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Product Detail

Means of Transport: Ocean,Land,Air
Packing: According to customer requi...
Brand: MOSINTER
Molecular weight: 429.9
Boiling point: 548.2°C at 760 mmHg
Melting point: 223-225°C
Production Capacity: 2 Ton/Year
Delivery Date: Within 7 days
Molecular formula: C22H24ClN3O4
Storage point: -20°C Freezer
Flashing point: 285.4°C
Vapour pressure: 4.52E-12mmHg at 25°C

Erlotinib hydrochloride is a drug used to treat non-small cell lung cancer (NSCLC), pancreatic cancer and several other types of cancer.

Erlotinib hydrochloride(CAS: 183319-69-9)

 

Item

Index

Molecular Formula

C22H23N3O4.HCl

Molecular Weight

429.90

Specification

CP/USP/EP

Content

≥99.0%

Erlotinib hydrochloride (trade name Tarceva) is a drug used to treat non-small cell lung cancer (NSCLC), pancreatic cancer and several other types of cancer. It is a reversible tyrosine kinase inhibitor, which acts on the epidermal growth factor receptor (EGFR). It is marketed in the United States by Genentech and OSI Pharmaceuticals and elsewhere byRoche.

Mechanism

Erlotinib is an EGFR inhibitor. The drug follows Iressa (gefitinib), which was the first drug of this type. Erlotinib specifically targets the epidermal growth factor receptor (EGFR) tyrosine kinase, which is highly expressed and occasionally mutated in various forms of cancer. It binds in a reversible fashion to the adenosine triphosphate (ATP) binding site of the receptor. For the signal to be transmitted, two EGFR molecules need to come together to form ahomodimer. These then use the molecule of ATP to trans-phosphorylate each other on tyrosine residues, which generates phosphotyrosine residues, recruiting the phosphotyrosine-binding proteins to EGFR to assemble protein complexes that transduce signal cascades to the nucleus or activate other cellular biochemical processes. By inhibiting the ATP, formation of phosphotyrosine residues in EGFR is not possible and the signal cascades are not initiated.


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Company Info

MOSINTER GROUP LIMITED [China (Mainland)]

sgs ico Offline Showroom in USA

Business Type:Manufacturer, Trading Company
City: Ningbo
Province/State: Zhejiang
Country/Region: China (Mainland)

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