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1 10-Phenanthroline Anhydrous CAS 66-71-7 10-Fenanthrolin o-Phenanthroline β-Phenanthroline phenanthroline 

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Place of Origin: Zhejiang, China (Mainland) 
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Product Detail

Means of Transport: Ocean,Land,Air
Packing: According to the customer r...
Brand Name: MOSINTER
Soluble: slightly soluble
Molecular formula: C12H8N2
Density: 1.31 g/cm3
Melting point: 117 °C (243 °F; 390 K)
S-phrases: S45,S60,S61
Production Capacity: 50 Ton/Year
Delivery Date: within 7 days
CAS No.: 66-71-7
Sensibility: Hygroscopic
Molar mass: 180.21 g/mol
Alias: 1,10-Phenanthroline hydrate
R-phrases: R25, R50/53

Peptidase inhibitor, Ferroin and analogues, Related phen ligands, A variety of substituted derivatives of phen have been examined as ligands.

1.10-Phenanthroline Anhydrous (CAS: 66-71-7)




Purity %≥


Residue on ignition (sulfate) %≤


Melting ℃


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Basic Information

Phenanthroline (phen) is a heterocyclic organic compound. It is a white solid that is soluble in organic solvents. It is used as a ligand incoordination chemistry, it forms strong complexes with most metal ions. In terms of its coordination properties, phen is similar to 2,2'-bipyridine.


Phenanthroline may be prepared by two successive Skraup reactions of glycerol with o-phenylenediamine, catalyzed by sulfuric acid, and an oxidizing agent, traditionally aqueous arsenic acid or nitrobenzene. Dehydration of glycerol gives acrolein which condenses with the amine followed by a cyclization.

Peptidase inhibitor

1,10-Phenanthroline is an inhibitor of metallopeptidases, with one of the first observed instances reported in carboxypeptidase A. Inhibition of the enzyme occurs by removal and chelation of the metal ion required for catalytic activity, leaving an inactive apoenzyme. 1,10-Phenanthroline targets mainly zinc metallopeptidases, with a much lower affinity for calcium.

Ferroin and analogues

The complex [Fe(phen)3]2+, called "ferroin," is used for the photometric determination of Fe(II). It is used as a redox indicator with standard potential +1.06 V. The reduced ferrous form has a deep red colour and the oxidised form is light-blue. Ferroin is used as a cell permeableinhibitor for metalloproteases in cell biology.

The pink complex [Ni(phen)3]2+ has been resolved into its Δ and Λ isomers. The analogous [Ru(phen)3]2+ has long been known to be bioactive.

Related phen ligands

A variety of substituted derivatives of phen have been examined as ligands. Neocuproine, 2,9-dimethyl-1,10-phenanthroline, is a bulky ligand. In "bathophenanthroline," the 4 and 7 positions are substituted by phenyl groups. The more electron-rich phenanthroline ligand is 3,4,7,8-tetramethyl-1,10-phenanthroline.

Numbering for 1,10-phenanthroline derivatives.

As an indicator for alkyllithium reagents

Alkyllithium reagents form deeply colored derivatives with phenanthroline. The alkyllithium content of solutions can be determined by treatment of such reagents with small amounts of phenanthroline (ca. 1 mg) followed by titration with alcohols to a colourless endpoint.

Grignard reagents may be similarly titrated.

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