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Pregnant mare serum gonadotropin CAS: 9002-70-4 

Payment Terms: T/T,L/C,WU 
Place of Origin: Sichuan, China (Mainland) 
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Means of Transport: Ocean,Land,Air
Packing: According to the customer r...
cas: 9002-70-4
storage condition: -20°C
Merck: 13,2237
Production Capacity: 1T/Year
Delivery Date: within 7 days
Brand: MOSINTER
solubility: saline: 1 mL/vial
form: lyophilized powder

Gonadotropins (or glycoprotein hormones) are protein hormones secreted by gonadotrope cells of the anterior pituitary of vertebrates.

Pregnant mare serum gonadotropin CAS: 9002-70-4Pregnant mare serum gonadotropin

CAS: 9002-70-4

 


Item

Index

Specification

CP/USP/EP

Appearance

lyophilized powder

Solubility

saline: 1 mL/vial

 Storage   Condition

−20°C

Gonadotropins (or glycoprotein hormones) are protein hormones secreted by gonadotrope cells of the anterior pituitary of vertebrates. This is a family of proteins, which include the mammalian hormones follicle-stimulating hormone (FSH), luteinizing hormone (LH), placental chorionic gonadotropins hCG and eCG and chorionic gonadotropin (CG), as well as at least two forms of fish gonadotropins. These hormones are central to the complex endocrine system that regulates normal growth, sexual development, and reproductive function.The hormones LH and FSH are secreted by the anterior pituitary gland, while hCG and eCG are secreted by the placenta.


Natural types and subunit structure

The two principal gonadotropins in vertebrates are luteinizing hormone (LH) and follicle-stimulating hormone (FSH), although primates produce a third gonadotropin called chorionic gonadotropin (CG). LH and FSH are heterodimers consisting of two peptide chains, an alpha chain and a beta chain. LH and FSH share nearly identical alpha chains (about 100 amino acids long), whereas the beta chain provides specificity for receptor interactions. These subunits are heavily modified by glycosylation.

The alpha subunit is common to each protein dimer (well conserved within species, but differing between them), and a unique beta subunit, which confers biological specificity. The alpha chains are highly conserved proteins of about 100 amino acid residues which contain ten conserved cysteines all involved in disulfide bonds, as shown in the following schematic representation.

Mechanism

gonadotropin-releasing hormone

Gonadotropin receptors are embedded in the surface of the target cell membranes and coupled to the G-protein system. Signals triggered by binding to the receptor are relayed within the cells by the cyclic AMP second messenger system.

Gonadotropins are released under the control of gonadotropin-releasing hormone (GnRH) from the arcuate nucleus and preoptic area of the hypothalamus. Thegonads — testes and ovaries — are the primary target organs for LH and FSH. The gonadotropins affect multiple cell types and elicit multiple responses from the target organs. As a simplified generalization, LH stimulates the Leydig cells of the testes and the theca cells of the ovaries to producetestosterone (and indirectly estradiol), whereas FSH stimulates the spermatogenic tissue of the testes and the granulosa cells of ovarian follicles.

Diseases

Gonadotropin deficiency due to pituitary disease results in hypogonadism, which can lead to infertility. Treatment includes administered gonadotropins, which, therefore, work as fertility medication. Such can either be produced by extraction and purification from urine or be produced by recombinant DNA.

Failure or loss of the gonads usually results in elevated levels of LH and FSH in the blood.

Pharmacologic preparations

Main article: Gonadotropin preparations

There are various preparations of gonadotropins for therapeutic use, mainly as fertility medication. For example, the so-called menotropins (also called human menopausal gonadotropins) consist of LH and FSH extracted from human urine from menopausal women. There are also recombinant variants.

 


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