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Acycloguanosine CAS 59277-89-3 aciclovir Acyclovir (Patented-No Supply) 

Payment Terms: T/T,L/C,WU 
Place of Origin: Shandong, China (Mainland) 
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Product Detail

Model No.: C8H11N5O3
Production Capacity: 20Ton/year
Delivery Date: within 7 days
cas: 59277-89-3
Melting Point: 256-257°C
Color: white
Stability: Stable. Incompatible with s...
Means of Transport: Ocean,Land,Air
Packing: According to request of cus...
Brand: MOSINTER
Storage condition: -20°C
Form: powder
Solubility: H2O: 0.7 mg/mL

If nursing mothers have herpetic lesions near or on the breast, breast-feeding should be avoided.

Acycloguanosine(CAS: 59277-89-3)

 

Item

Index

Molecular   Formula

C8H11N5O3

Molecular weight

225.2

Specification

CP/USP/EP

Appearance

White powder

Melting point

256-257°C

Solubility(in   water)

0.7 mg/ml

 

Aciclovir (INN, BAN. Brand names: Cyclovir, Herpex, Acivir, Acivirax, Zovirax, Zoral, Xovir and Imavir)  or acyclovir (USAN, former BAN), chemical name acycloguanosine, abbreviated as ACV,  is a guanosine analogue antiviral drug. It is one of the most commonly used antiviral medicine, that is primarily used for the treatment of herpes simplex virus infections, as well as in the treatment of varicella zoster (chickenpox) and herpes zoster (shingles).

It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.

Medical use

Aciclovir is indicated for the treatment of HSV and VZV infections, including:

•     Genital herpes simplex (treatment and prevention)

•     Herpes simplex labialis (cold sores)

•     Shingles

•     Acute chickenpox in immunocompromised patients

•     Herpes simplex encephalitis

•     Acute mucocutaneous HSV infections in immunocompromised patients

•     Herpes of the eye

•     Herpes simplex blepharitis (a chronic (long-term) form of herpes eye infection)

•     Prophylaxis against herpes viruses in immunocompromised patients (such as patients undergoing cancer chemotherapy)

It has been claimed that the evidence for the effectiveness of topically applied cream for recurrent labial outbreaks is weak. An earlier review of scientific literature showed there is some effect in reducing the number and duration of lesions if aciclovir is applied at an early stage of an outbreak. Aciclovir trials show that this agent has no role in preventing HIV transmission, but it can help slow HIV disease progression in people not taking anti-retroviral therapy (ART). This finding emphasizes the importance of testing simple, inexpensive non-ART strategies, such as aciclovir andcotrimoxazole, in people with HIV.

A systematic review found that in the treatment of individuals suffering from herpes of the eye, aciclovir was found to be significantly more effective than idoxuridine or vidarabine in relative number of successfully healed eyes.

Pregnancy

Classified as a Category B Drug, the CDC and others have declared that during severe recurrent or first episodes of genital herpes, aciclovir may be used. For severe HSV infections (especially disseminated HSV), IV aciclovir may also be used. Studies in mice, rabbits and rats (with doses more than 10 times the equivalent of that used in humans) given during organogenesis have failed to demonstrate birth defects. Studies in rats in which they were given the equivalent to 63 times the standard steady-state humans concentrations of the drug on day 10 of gestation showed head and tail anomalies.

Aciclovir is recommended by the CDC for treatment of Varicella during pregnancy, especially during the second and third trimesters.

Aciclovir is excreted in the breast milk, therefore it is recommended that caution should be used in breast-feeding women. It has been shown in limited studies that the nursing infant is exposed to approximately 0.3 mg/kg/day following oral administration of aciclovir to the mother. If nursing mothers have herpetic lesions near or on the breast, breast-feeding should be avoided.

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MOSINTER GROUP LIMITED [China (Mainland)]

Offline Showroom in USA

Business Type:Manufacturer, Trading Company
City: Ningbo
Province/State: Zhejiang
Country/Region: China (Mainland)

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