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Naproxen Sodium CAS 26159-34- 2 sodiumnaprosyn 

Payment Terms: T/T,L/C,WU 
Place of Origin: Zhejiang, China (Mainland) 
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Product Detail

Model No.: 26159-34-2
Production Capacity: 200Tons / month
Delivery Date: within 7 days
Purity %≥: 99.0
Brand: MOSINTER
Molecular weight: 252.24
Specification: CP/USP/EP
Means of Transport: Ocean,Land,Air
Packing: As per request of clients
Appearance: white powder
Name: 6-methoxy-alpha-methyl-,sod...
Molecular Formula: C14H13O3.Na
Melting point: 250-251°C
Storage Condition: Desiccate at RT

Naproxen is commonly used for the reduction of pain, fever, inflammation, and stiffness caused by conditions including migraine

Naproxen Sodium CAS: (26159-34-2)


Item

Index

Molecular   Formula

C14H13O3.Na

Molecular weight

252.24

Specification

CP/USP/EP

Melting point

250-251°C

 Storage Condition

Desiccate at RT

 Naproxen (INN; brand names: Aleve, Naprosyn and many others) usually sold as the sodium salt naproxen sodium is a nonsteroidal anti-inflammatory drug (NSAID) of the propionic acid class (which puts it in the same class as ibuprofen) and is commonly used for relief of a wide variety of pain, fever, swelling and stiffness.:665,673 It is the preferred NSAID for long-term use in people with a high risk of cardiovascular (for example, heart attacks or strokes) complications, due to its relatively low risk of causing such complications. Naproxen has an intermediate risk of causing stomach ulcers as compared with ibuprofen, which is low risk, and indometacin, which is high risk. In order to reduce the risk of stomach ulceration, it is often combined with a proton-pump inhibitor (a medication that reduces the production of stomach acid) during long-term treatment, in those with pre-existing stomach ulcers, or a history of developing stomach ulcers while on NSAIDs.

Medical uses

Naproxen is commonly used for the reduction of pain, fever, inflammation, and stiffness caused by conditions including migraine, osteoarthritis,kidney stones, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, menstrual cramps, tendinitis, and bursitis, among others. It is also used for the treatment of primary dysmenorrhea.

Diagnostics

Naproxen has been utilized to differentiate between infectious fevers and those with neoplastic or connective tissue disease related fevers.

Adverse effects

COX-2 selective and nonselective NSAIDs have been linked to increases in the number of serious and potentially fatal cardiovascular events, such asmyocardial infarctions and strokes. Naproxen is, however, associated with the smallest overall cardiovascular risks. Cardiovascular risk needs to be taken into account when prescribing any non-steroidal anti-inflammatory drug. The drug had roughly 50% of the associated risk of stroke as compared with ibuprofen and was also associated with a reduced number of myocardial infarctions as compared to control groups. As with other non-COX-2 selective NSAIDs, naproxen can cause gastrointestinal problems, such as heartburn, constipation, diarrhea, ulcers and stomach bleeding.Persons with a history of ulcers or inflammatory bowel disease should consult a doctor before taking naproxen.

It was found that high-dose naproxen induced near-complete suppression of platelet thromboxane throughout the dosing interval and appeared not to increase cardiovascular disease (CVD) risk, whereas other high-dose NSAID regimens had only transient effects on platelet COX-1 and were associated "with a small but definite vascular hazard". Conversely, naproxen was associated with higher rates of upper gastrointestinal bleeding complications in comparison to other NSAIDs.

NSAID painkillers, such as naproxen, may interfere with and reduce the efficacy of SSRI antidepressants.[10]

Mechanism of action

Naproxen works by reversibly inhibiting both the COX-1 and COX-2 enzymes.


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Company Info

MOSINTER GROUP LIMITED [China (Mainland)]

Offline Showroom in USA

Business Type:Manufacturer, Trading Company
City: Ningbo
Province/State: Zhejiang
Country/Region: China (Mainland)

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