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MOSINTER GROUP LIMITED
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Dipyrone CAS 5907-38-0 Analgin Alginic acid ammoniumsalt Ammoniumalginate 

Payment Terms: T/T,L/C,WU 
Place of Origin: Zhejiang, China (Mainland) 
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Product Detail

Model No.: MOSINTER
Production Capacity: 200Ton/Year
Delivery Date: Within 7 days
Means of Transport: Ocean,Land,Air
Packing: According to the request of...
cas: 5907-38-0

It is primarily used for perioperative pain, although the clinical trial data to support this use is limited at best.

Dipyrone(CAS: 5907-38-0)

 

Item

Index

Molecular formula

C13H16N3O4S.Na

Molecular weight

333.34

Specification

CP/USP/EP

Appearance

White or light yellow

crystalline powder

 Storage   Condition

2-8°C


Metamizole (INN), or dipyrone (BAN, USAN)
, is a ampyrone sulfonate analgesic (pain reliever), antispasmodic (spasm reliever) and antipyretic (fever reducer) similar to paracetamol in that it has minimal anti-inflammatory effects and which is most commonly given orally or parenterally (by injection) to prevent and treat pain related to surgery or for the treatment of acute pain. It was first introduced into clinical use inGermanyin 1921 and for many years it was available over-the-counter in most countries, until its toxicities became so readily apparent, although in some countries it is available over-the-counter, its use is usually restricted in developed countries, due to its potential for causing toxic reactions.

Metamizole is marketed under various trade names, including Algozone, Algocalmin, Algopyrin, Analgin, Dipirona, Novalgin, Neo-Melubrina and Optalgin . Metamizole has been used for decades in many European (excluding the UK, but including most of continental Europe, including Germany, Italy, Russia,Spain and Turkey), Asian (China, India, Indonesia and Thailand included), African (including South Africa) and South American (including Argentina andBrazil) countries, despite this, it has been found to have a potentially fatal side effect of agranulocytosis (a dangerously compromised immune system; its rate varies significantly country-to-country), aplastic anaemia and hypersensitivity reactions (like allergic reactions such as anaphylaxis).

It was once widely combined with various other active ingredients, but since concerns over its safety have been raised in the late 1960s and 1970s its use in combination products has been in decline and in some countries, banned. Regardless, some national medical authorities (such as in Australia andUnited States ofAmerica) have withdrawn metamizole from the market altogether or have restricted it to be available only with a prescription, although it remains available over the counter in some countries.

Despite its potential haematologic (blood-related) toxicity (that is potential for causing blood dyscrasias) it produces no clinically relevant effects in the way of kidney toxicity, cardiovascular toxicity and GI toxicity when compared to non-steroidal anti-inflammatory medicine (NSAIDs). Unlikeparacetamol and similarly to the NSAIDs it can trigger bronchospasm or anaphylaxis, especially in those with asthma.


Medical uses

It is primarily used for perioperative pain, although the clinical trial data to support this use is limited at best. It is also used for acute injury, colic, cancer pain, other acute/chronic forms of pain and high fever unresponsive to other agents.

Special populations

Its use in pregnancy is advised against, although animal studies are reassuring in that they show minimal risk of birth defects; its use in the elderly or those with liver/kidney impairment is advised against, but if these groups of people must be treated a lower dose and caution is usually advised; its use in lactation is advised against as it is excreted in breast milk.

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Company Info

MOSINTER GROUP LIMITED [China (Mainland)]

Offline Showroom in USA

Business Type:Manufacturer, Trading Company
City: Ningbo
Province/State: Zhejiang
Country/Region: China (Mainland)

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