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Alpha-methyldopa CAS 555-30-6 METHYLDOPA 3-Hydroxy-alpha-methyl-L-tyrosine 

Payment Terms: T/T,L/C,WU 
Place of Origin: Sichuan, China (Mainland) 
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Product Detail

Model No.: C10H13NO4
Production Capacity: 100Ton/Year
Delivery Date: Within 7 days
Molecular formula: C10H13NO4
Melting Point: ≥300 °C
Boiling point: 436.3°C at 760 mmHg
Flashing point: 217.7°C
Means of Transport: Ocean,Land,Air
Packing: According to the request of...
Molecular weight: 211.21
Storage condition: Store at RT
Refractive index: -14 ° (C=1, H2O)
Vapour pressure: 2.19E-08mmHg at 25°C

Left-handed methyldopa is a B blockers core vascular medicine, to moderate program of primary and renal hypertension has good curative effect.

Alpha-methyldopa (CAS: 555-30-6)



Molecular Formula


Molecular weight





White crystalline powder

Melting point

≥300 °C

Refractive index

-14 ° (C=1, H2O)

 Storage   Condition

Store at RT

Chemical property

White crystalline powder. Soluble in dilute hydrochloric acid, at 25 ℃ in the water solubility of about 10 mg/ml, saturated water solution pH value is about 5. Slightly soluble in ethanol, insoluble in ether and chloroform.

Production methodprocess

Vanilla aldehyde with dimethyl sulfate methyl hellebore aldehyde, again with the nitro oxide condensation get 1 - (2 - nitro propenyl) - 3 ', 4 '- dimethoxy benzene, with iron powder reduction and generated after hydrolysis of 3', 4 '- dimethoxy benzene acetone, Then by cyclization, open loop, hydrolysis reaction to get DL - methyldopa, split out quick methyldopa left-handed.


Left-handed methyldopa is a B blockers core vascular medicine, to moderate program of primary and renal hypertension has good curative effect.

Methyldopa(L-α-Methyl-3,4-dihydroxyphenylalanine; Aldomet, Aldoril, Dopamet, Dopegyt, etc.) is an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive drug used as a sympatholytic or antihypertensive. Its use is now mostly deprecated following the introduction of alternative safer classes of agents. However, it continues to have a role in otherwise difficult to treat hypertension and gestational hypertension (previously known as pregnancy-induced hypertension (PIH)).

It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.

Medical uses

Methyldopa is used in the clinical treatment of the following disorders:

Hypertension (or high blood pressure)

Gestational hypertension (or pregnancy-induced hypertension) and pre-eclampsia

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