Offline Showroom in USA
Post Offer Free
MOSINTER GROUP LIMITED
MOSINTER GROUP LIMITED  

Gold Index: 82941

You are here: home  > Pharmaceutical Chemicals API  > Circulatory System Drugs API  > Felodipine CAS 86189-69-7 Brn 4331472

Felodipine CAS 86189-69-7 Brn 4331472 

Payment Terms: T/T,L/C,WU 
Place of Origin: Zhejiang, China (Mainland) 
inquire skype
Add to My Favorites
HiSupplier Escrow
Share |

Product Detail

Model No.: C18H19Cl2NO4
Production Capacity: 10Ton/YEAR
Delivery Date: ithin 7 days
Molecular Weight: 384.2538
Melting point: 142-145℃
Flash point: 239°C
Brand: MOSINTER
Means of Transport: Ocean,Land,Air
Packing: s per request of clients
Molecular Formula: C18H19Cl2NO4
Specification: CP/USP/EP
Density: 1.277g/cm3
Boling point: 471.5°C at 760 mmHg

Felodipine is a calcium channel blocker (calcium antagonist), a drug used to control hypertension (high blood pressure).

Felodipine( CAS: 86189-69-7 )


Item

Index

Molecular Formula

C18H19Cl2NO4

Molecular Weight

384.2538

Specification

CP/USP/EP

Density

1.277g/cm3

Melting point

142-145℃

Boling point

471.5°C at 760 mmHg

Flash point

239°C


Felodipine is a calcium channel blocker (calcium antagonist), a drug used to control hypertension (high blood pressure). It is marketed under the brand name Plendil by AstraZeneca and Renedil by Sanofi-Aventis. The formulation patent for the substance expired in 2007.

AstraZeneca dropped Plendil from its support and AZ&Me free Rx access program in October 2008.

Interactions

Studies dating back to 1989 have suggested that felodipine in combination with grapefruit juice can cause toxic effects. Oral administration of felodipine is first metabolized in the gastrointestinal tract and liver by the enzyme CYP3A4. Grapefruit juice contains bergamottin which is found to have an inhibiting effect over this enzyme and as a result the bioavailability of the drug increases, raising the risk for abnormal side effects.[2]

Contraindications and cautions

Contraindicated with allergy to felodipine or other calcium channel blockers, sick sinus syndrome, heart block (second and third degree), lactation. Use cautiously with pregnancy, impaired hepatic function.

Felodipine for High Blood Pressure

A blood pressure reading consists of two numbers -- for example, 120/80. The top number is known as the systolic blood pressure, and the bottom number is the diastolic blood pressure. High blood pressure is defined as an average blood pressure higher than 140/90, with multiple blood pressure readings.

 

Based on clinical studies, felodipine has been shown to significantly lower systolic and diastolic blood pressure. By lowering blood pressure, felodipine can decrease the risk of developing health problems, such as a stroke, heart disease, or congestive heart failure, which can occur with long-term high blood pressure (seeEffects of High Blood Pressure). However, felodipine is not a cure for high blood pressure. Felodipine is approved for use alone or in combination with other blood pressure medications.

 

What Is Felodipine Used For?

Felodipine is used for treating high blood pressure in adults. It is a type of calcium channel blocker, which works to decrease diastolic and systolic blood pressure by relaxing the blood vessels. By lowering blood pressure, felodipine can decrease the risk of developing health problems (such as strokes and heart disease), which can occur with long-term high blood pressure. Possible off-label felodipine uses include treating chest pain.

How Felodipine Works

Felodipine is part of a class of medicine called calcium channel blockers. It helps to slow down the rate at which calcium moves into your heart and blood vessel walls. This, in turn, helps to relax the blood vessels, which improves blood flow and lowers blood pressure. It also makes it easier for the heart to pump blood.

 

There are two basic types of calcium channel blockers: dihydropyridine and non-dihydropyridine. The most important difference between the two types is that non-dihydropyridine calcium channel blockers can slow down the heart rate, while dihydropyridine calcium channel blockers do not. Felodipine is a dihydropyridine calcium channel blocker, which means that it does not have an effect on the heart rate.

bigPhoto
skype Mr. Fedor

Tel: +86-574-89212210
Fax: +86-574-89212215
Mobile: 86- 189 8930 5995
Contact to this supplier

Didn't find what you're looking for? Post Buying Lead or contact HiSupplier Customer Service Center  for help!

Related Search

Find more related products in following catalogs on Hisupplier.com

Company Info

MOSINTER GROUP LIMITED [China (Mainland)]

Offline Showroom in USA

Business Type:Manufacturer, Trading Company
City: Ningbo
Province/State: Zhejiang
Country/Region: China (Mainland)

Follow Us: Follow us on facebook Follow us on linkedin

Fedor:   skype

You May Like: