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Manidipine hydrochloride CAS 89226-75-5 4-(diphenylmethyl)-1-piperazinyl)ethylmethylester dihydrochloride 

Payment Terms: T/T,L/C,WU 
Place of Origin: Sichuan, China (Mainland) 
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Product Detail

Model No.: C35H38N4O6 2HCl
Production Capacity: 14T/Year
Delivery Date: within 7 days
CAS: 89226-75-5
Specification: CP/USP/EP
Melting point: 174~182℃
Total impurities: ≤ 1.0%
Loss on drying: ≤6.0%
Means of Transport: Ocean,Land,Air
Packing: According to the customer r...
Molecular Formula: C35H38N4O6 2HCl
Molecular Weight: 683.62
Content: 98.0%~101.5%
Cefotaxime: ≤0.5%

Free base for light yellow crystal for first grade. Insoluble in water, soluble in ether, mp125 ~ 128 ℃.

Manidipine hydrochloride (CAS: 89226-75-5)



Molecular Formula


Molecular Weight




Pharmacologic action

For two hydrogen pyridine class calcium antagonist medicine, high selectivity of blood vessels, step-down effect is strong and durable, can increase renal blood flow, central The effect of dirty is weak. Oral absorption, blood drug concentration peak time 1 ~ 2 hours. In the plasma and protein at a rate of 97%. T1/2 for about 5 hours.

Adaptation disease

Used for high blood pressure, especially in low renin patients with high blood pressure. Also apply for kidney function has been damage.

Untoward effect

The adverse reaction similar nifedipine, accidentally saw a liver or kidney dysfunction, leukopenia, etc.


Free base for light yellow crystal for first grade. Insoluble in water, soluble in ether, mp125 ~ 128 ℃. A homogeneous crystal, alpha model for yellow crystal, insoluble in ethanol, acetone and ethyl ether, soluble in water. Mp157 ~ 163 ℃; Beta is light yellow fine crystal, insoluble in ethanol, ether and acetone, soluble in water. Mp174 ~ 180 ℃.


Calcium channel blockers. Have stronger relaxation arterial smooth muscle, blood vessels, reduce the role of peripheral vascular resistance and arterial pressure. Used in the treatment of essential hypertension, type of low renin hypertension antihypertensive effect is more obvious, and can improve the uric acid metabolism.

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