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MOSINTER GROUP LIMITED
MOSINTER GROUP LIMITED

China Granisetron hydrochloride CAS 107007-99-8 KYTRIL BRL-43694A GRANISERTROL HYDROCHLORIDE GRANISETRON HCL manufacturer

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Granisetron hydrochloride CAS 107007-99-8 KYTRIL BRL-43694A GRANISERTROL HYDROCHLORIDE GRANISETRON HCL 

Payment Terms: T/T,L/C,WU 
Place of Origin: Shandong, China (Mainland) 
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Product Detail

Means of Transport: Ocean,Land,Air
Packing: According to the request of...
Brand: MOSINTER
Molecular Weight: 312.4094
Flash point: 275.553°C
Boiling point: 532.016°C at 760 mmHg
Production Capacity: 20Ton/Year
Delivery Date: Within 7 days
Molecular Formula: C18H24N4O
Specification: CP/USP/EP
Density: 1.33g/cm3

Granisetron is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.

Granisetron hydrochloride (CAS: 107007-99-8)


Item

Index

Molecular Formula

C18H24N4O

Molecular Weight

312.4094

Specification

CP/USP/EP

Density

1.33g/cm3

Boiling point

532.016°C at 760 mmHg

Flash point

275.553°C

Granisetron is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy. Its main effect is to reduce the activity of the vagus nerve, which is a nerve that activates the vomiting center in the medulla oblongata. It does not have much effect on vomiting due to motion sickness. This drug does not have any effect on dopamine receptors or muscarinic receptors.

Granisetron was developed by chemists working at the British drug company Beecham around 1988 and is available as a generic. It is produced by Roche Laboratories under the trade name Kytril. The drug was approved in theUnited Kingdomin 1991 and inUnited Statesin 1994 by the FDA.

A granisetron transdermal patch with the trade name Sancuso was approved by the US FDA on September 12, 2008. Sancuso is manufactured by ProStrakan, Inc., a pharmaceutical company headquartered in Bedminster, NJ, with global headquarters inScotland.

Granisetron is metabolized slowly by the liver, giving it a longer than average half-life. One dose usually lasts 4 to 9 hours and is usually administered once or twice daily. This drug is removed from the body by the liver and kidneys.


Medical uses

Chemotherapy

It may be used for chemotherapy-induced nausea and vomiting and appears to work about the same as ondansetron.

Post operative

A number of medications including granisetron appear to be effective in controlling post-operative nausea and vomiting (PONV). It is unclear if it is more or less effective than other agents such as droperidol, metoclopramide, ondansetron or cyclizine.

Its efficacy has also been questioned with a research Dr. Yoshitaka Fujii having 12 published papers on this topic in Canadian Journal of Anesthesia retracted. A further five papers in the same journal on the same drug by Dr Fujii are considered indeterminate.

Other

Is a possible therapy for nausea and vomiting due to acute or chronic medical illness or acute gastroenteritis

Treatment of cyclic vomiting syndrome although there are no formal trials to confirm efficacy.

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Company Info

MOSINTER GROUP LIMITED [China (Mainland)]

sgs ico Offline Showroom in USA

Business Type:Manufacturer, Trading Company
City: Ningbo
Province/State: Zhejiang
Country/Region: China (Mainland)

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