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MOSINTER GROUP LIMITED
MOSINTER GROUP LIMITED

China Mitoxantrone hydrochloride CAS 70476-82-3 DHAQ DIHYDROCHLORIDE manufacturer

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Mitoxantrone hydrochloride CAS 70476-82-3 DHAQ DIHYDROCHLORIDE 

Payment Terms: T/T,L/C,WU 
Place of Origin: Zhejiang, China (Mainland) 
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Product Detail

Means of Transport: Ocean,Land,Air
Packing: As per request of clients
Molecular Formula: C22H30Cl2N4O6
Molecular Weight: 517.4
Appearance: Dark blue powder
Heavy metal: 20ppm Max
PH: 3.0-5.5
Production Capacity: 1000 KG/YEAR
Delivery Date: within 7 days
Specification: CP/USP/EP
Brand: MOSINTER
loss on drying: 6.0%MAX
Purity: 97%~102%

It is used in the treatment of certain types of cancer, mostly metastatic breast cancer, acute myeloid leukemia, and non-Hodgkin's lymphoma.

Mitoxantrone hydrochloride (CAS: 70476-82-3)


Item

Index

Molecular Formula

C22H30Cl2N4O6

Molecular Weight

517.4

Specification

CP/USP/EP

Purity

97%~102%

Loss on drying

6.0%MAX

Heavy metal

20ppm Max

PH

3.0-5.5

Appearance

Appearance


Mitoxantrone (INN, BAN, USAN. Also known as Mitozantrone (is the generic name in Australia)) is an anthracenedione (not an anthracycline)antineoplastic agent.

Uses

It is used in the treatment of certain types of cancer, mostly metastatic breast cancer, acute myeloid leukemia, and non-Hodgkin's lymphoma. It was also shown to improve the survival of children suffering from first relapse of acute lymphoblastic leukaemia.

The combination of mitoxantrone and prednisone is approved as a second-line treatment for metastatic hormone-refractory prostate cancer. This combination has been the first line of treatment, until recently, when combination of docetaxel and prednisone has been shown to improve survival and disease-free period.


Mitoxantrone is also used to treat multiple sclerosis (MS), most notably the subset known as secondary progressive MS. Mitoxantrone will not cure multiple sclerosis, but is effective in slowing the progression of secondary progressive MS and extending the time between relapses in relapsing-remitting MS and progressive relapsing MS.

Mechanism of action

Human topoisomerase iibeta in complex with DNA and mitoxantrone. PDB entry 4g0v. Detail showing mitoxantrone (spheres) intercalated with DNA.

Mitoxantrone is a type II topoisomerase inhibitor; it disrupts DNA synthesis and DNA repair in both healthy cells and cancer cells, by intercalation. between the DNA bases.

Side effects

As other medicine in its class, mitoxantrone may cause several adverse reactions of varying severity, such asnausea, vomiting, hair loss, heart damage, and immunosuppression. Some side effects may have delayed onset.Cardiomyopathy is a particularly concerning effect as it is irreversible; regular monitoring withechocardiograms or MUGA scans is recommended for people taking mitoxantrone.

The medication carries a total lifetime dose based on body surface area.

Synthesis

Mitoxantrone can be prepared from quinizarin:

Mitoxantrone, 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl) amino)ethyl]amino]]-9,10-anthracendione, is structurally related to the antibiotic doxorubicine. It is synthesized from danthron (1,8-dihydroxyanthraquinone), which when reacted with nitric acid, and then a mixture of sodium sulfide and thiosulfate in a base, is transformed to 1,4,5,8-tetrahydroxyanthraquinone. Reacting this with 2-aminoethylaminoethanol in the presence of chloranyl (2,3,5,6-tetrachlorobenzoquinone-1,4) gives the desired mitoxantrone.

  • F.E. Durr, K.C. Murdock, U.S. Patent 4,197,249 (1980).

  • K.C. Murdock, F.E. Durr, R.G. Child, DE 2835661 (1979).

  • Zee-Cheng, R. K. Y.; Cheng, C. C. (1978). "Antineoplastic agents. Structure-activity relationship study of bis(substituted aminoalkylamino)anthraquinones". Journal of Medicinal Chemistry 21 (3): 291. doi:10.1021/jm00201a012. PMID 628005. edit

  • Murdock, K. C.; Child, R. G.; Fabio, P. F.; Angier, R. D.; Wallace, R. E.; Durr, F. E.; Citarella, R. V. (1979). "Antitumor agents. 1. 1,4-Bis[(aminoalkyl)amino]-9,10-anthracenediones".Journal of Medicinal Chemistry 22 (9): 1024. doi:10.1021/jm00195a002. PMID 490545. edit

  • The mechanism of its action is not completely understood, although it is presumed, that mitoxantrone acts by binding with DNA, thus disturbing the twisting process of the chains. It is used intravenously for treating severe nonlymphatic leukemia, breast cancer, and so on.

    A synonym of this drug is novantrone.



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Company Info

MOSINTER GROUP LIMITED [China (Mainland)]

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Business Type:Manufacturer, Trading Company
City: Ningbo
Province/State: Zhejiang
Country/Region: China (Mainland)

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