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MOSINTER GROUP LIMITED
MOSINTER GROUP LIMITED

China 10-Hydroxycamptothecin CAS 64439-81-2 Hydroxy camptothecine manufacturer

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10-Hydroxycamptothecin CAS 64439-81-2 Hydroxy camptothecine 

Payment Terms: T/T,L/C,WU 
Place of Origin: Shandong, China (Mainland) 
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Product Detail

Means of Transport: Ocean,Land,Air
Packing: According to the request of...
Brand: MOSINTER
Specification: CP/USP/EP
Melting Point: 230-237°C
Storage condition: -20°C
Boiling point: 820.7°C at 760 mmHg
Production Capacity: 100 KG/Year
Delivery Date: within 7 days
Molecular Formula: C20H24N2O6
Appearance: Yellow crystalline powder
Molecular Weight: 388.42
Density: 1.60
Flashing point: 450.1°C

10-Hydroxycamptothecin is the derivative of camptothecine that is a micro-alkaloid from camptotheca Acuminate

10-Hydroxycamptothecin ( CAS: 64439-81-2 ) 


Item

Index

Molecular Formula

C20H16N2O5

Molecular Weight

364.35

Specification

CP/USP/EP

Content

99%(HPLC)


10-Hydroxycamptothecin is the derivative of camptothecine that is a micro-alkaloid from camptotheca Acuminate (a tree native to mainland China). is a kind of pharmaceutical intermediate, an alkaloid originally isolated from the Camptotheca acuminata, exerted inhibitory effects on DNA topoisomerase (Topo )[1]and has anticancer activity in vitro and in vivo. It can also induce differentiation of leukemia MELC and HL-60cells.

10-Hydroxycamptothecin is a DNA topoisomerase I inhibitor with potent anti-tumor activity. Compared with camptothecin (CPT), 10-Hydroxycamptothecin has a longer-lived cleavable complex, and is substantially more cytotoxic against cancer cells, indicating that the persistence of cleavable complexes may be an essential property for increasing the likelihood of a collision between the replication fork and a cleavable complex, giving rise to lethal DNA lesions. [1]10-Hydroxycamptotheci treatment significantly inhibits angiogenesis both in vitro and in vivo at relatively low concentrations, and this effect is related with induction of apoptosis in human microvascular endothelial cells (HMEC). 10-Hydroxycamptothecin significantly represses the proliferation of Colo 205 cells at a relatively low concentration (5-20 nM). 10-Hydroxycamptothecin treatment induces Colo 205 cells arrested in the G2 phase, and triggers caspase-3-dependent apoptosis. Consistently, oral administration of 10-Hydroxycamptothecin at a relatively low dose is able to inhibit the growth of Colo 205 xenografts in mice.

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Company Info

MOSINTER GROUP LIMITED [China (Mainland)]

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Business Type:Manufacturer, Trading Company
City: Ningbo
Province/State: Zhejiang
Country/Region: China (Mainland)

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