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MOSINTER GROUP LIMITED
MOSINTER GROUP LIMITED

China Doxifluridine CAS 3094-09-5 flutron furtulon DOXIFLURIDINE Doxifluridine manufacturer

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Doxifluridine CAS 3094-09-5 flutron furtulon DOXIFLURIDINE Doxifluridine 

Payment Terms: T/T,L/C,WU 
Place of Origin: Sichuan, China (Mainland) 
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Product Detail

Model No.: C9H11O5N2F
Production Capacity: 10 Ton/year
Delivery Date: within 7 days
CAS: 3094-09-5
Molecular Weight: 246.2
Specification: CP/USP/EP
Name: Doxifluridine
Alias: flutron
Means of Transport: Ocean,Land,Air
Packing: According to the request of...
Brand: MOSINTER
Molecular Formula: C9H11O5N2F
Appearance: white crystalline powder
Assay: ≥98.5%
Identification: Conform to

Doxifluridine is a fluorinated pyrimidine nucleoside, which displays cytostatic activity.

Doxifluridine ( CAS: 3094-09-5 )

 

Item

Index

Molecular Formula

C9H11O5N2F

Molecular Weight

246.2

Specification

CP/USP/EP

Appearance

white crystalline powder

Melting point

189.0~193.0℃

specific rotation

+18.5°- +21.5°

Identification

Conform to

PH value

4.0 - 6.0

Assay

≥98.5%

Doxifluridine is a fluorinated pyrimidine nucleoside, which displays cytostatic activity. It is known that this compound is the inactive form of 5-Fluorouridine (sc-221027), which is converted by enzymes in vivo . Studies indicate that 5-Fluorouridine causes apoptosis in HCT-116 colorectal carcinoma cells and along with cDNA microarray is a useful tool in studying the expression of 1,200 genes during apoptosis. It is believed that 5-Fluorouridine induces cytotoxicity in cells not only by inhibition of RNA synthesis and processing, but through other unknown mechanisms as well.

Chemistry


IUPAC Name: 1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-methyloxolan-2-yl]-5-fluoropyrimidine-2,4-dione 

Empirical Formula: C9H11FN2O5 

Molecular Weight: 246.1924 

EINECS: 221-440-1

Product Categories: Heterocycles; Pyridines, Pyrimidines, Purines and Pteredines; Pyrazines, Pyrimidines & Pyridazines; API intermediates; Biochemistry; Chemical Reagents for Pharmacology Research; Nucleosides and their analogs; Nucleosides, Nucleotides & Related Reagents; Bases & Related Reagents; Nucleotides; Intermediates & Fine Chemicals; Pharmaceuticals; Pyrazines, Pyrimidines & Pyridazines 

Index of Refraction: 1.605 

Molar Refractivity: 51.91 cm3 

Molar Volume: 150.6 cm3 

Surface Tension: 69.8 dyne/cm 

Density: 1.63 g/cm3 

Appearance: White Solid

Melting Point: 188-192 °C(lit.)

Classification Code of Doxifluridine (CAS NO.3094-09-5): Antimetabolites; Antimetabolites, Antineoplastic; Antineoplastic agents; Central Nervous System Agents;  Drug / Therapeutic Agent; Immunologic Factors; Immunosuppressive agents; Mutation data; Noxae; Reproductive Effect

Uses

Doxifluridine (CAS NO.3094-09-5) is a prodrug of 5-Flurouridine and a fluorinated pyrimidine nucleoside with cytostatic activity. It is used as an antitumor agent efficient in tumors, cell lines or in fibroblasts tranformed by H-ras or trk oncogenes. A metabolite of Capecitabine .

Safety Profile

Hazard Codes:Xi  
WGK Germany :2 
RTECS:YU7526000 
Hazard Note:Irritant 
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin. 
Safety Statements: 26-36 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36:Wear suitable protective clothing. 
HazardClass: IRRITANT, IRRITANT-HARMFUL

Specification

Doxifluridine (CAS NO.3094-09-5), its Synonyms are 1-(beta-D-5-Desoxyribofuranoxyl)-5-fluoruracil ; 5'-Deoxy-5-fluorouridine ; 5'-Dfur ; 5'-Doxifluridine ; Doxifluridina ; Flutron ; Furtulon ; Doxifluridinum ; Uridine, 5'-deoxy-5-fluoro- ; Uridine-5'-deoxy-5-fluoro- .

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Company Info

MOSINTER GROUP LIMITED [China (Mainland)]

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Business Type:Manufacturer, Trading Company
City: Ningbo
Province/State: Zhejiang
Country/Region: China (Mainland)

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