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MOSINTER GROUP LIMITED
MOSINTER GROUP LIMITED

China 5-Fluorouracil CAS 51-21-8 Fluorouracilum manufacturer

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5-Fluorouracil CAS 51-21-8 Fluorouracilum 

Payment Terms: T/T,L/C,WU 
Place of Origin: Shandong, China (Mainland) 
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Product Detail

Model No.: CAS: 51-21-8
Production Capacity: 100 Ton/Year
Delivery Date: within 7 days
Melting point: 282-286 °C (dec.)(lit.)
Storage condition: Store at 0-5
Form: powder
Soluble: 12.2 g/L 20 ºC
Stability: Stable. Light sensitive. Co...
Means of Transport: Ocean,Land,Air
Packing: According to the request of...
Brand: MOSINTER
Boiling point: 190-200°C/0.1mmHg
Solubility: H2O: 10 mg/mL, clear
Color: White
Sensibility: Air Sensitive

Fluorouracil has been given systemically for anal, breast, colorectal, oesophageal, stomach, pancreatic and skin cancers(especially head and neck canc

5-Fluorouracil (CAS: 51-21-8)


Item

Index

Molecular Formula

C4H3FN2O2

Molecular Weight

130.08

Specification

CP/USP/EP

Melting point

282-286 °C (dec.)(lit.)

Boiling point

190-200°C/0.1mmHg

 

Fluorouracil  or 5-FU (trademarked as Adrucil (IV), Carac (topical), Efudex (topical)) is a drugthat is a pyrimidine analog which is used in the treatment of cancer. It is a suicide inhibitor and works through irreversible inhibition of thymidylate synthase. It belongs to the family of drugs called the antimetabolites.

It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.

Medical uses

Fluorouracil has been given systemically for anal, breast, colorectal, oesophageal, stomach, pancreatic and skin cancers(especially head and neck cancers). It has also been given topically for actinic keratoses and Bowen's disease.

Mechanism of action

The chemotherapy agent 5-FU, which has been used against cancer for about 40 years, acts in several ways, but principally as a thymidylate synthase (TS) inhibitor. Interrupting the action of this enzyme blocks synthesis of the pyrimidine thymidine, which is a nucleoside required for DNA replication. Thymidylate synthase methylates deoxyuridine monophosphate (dUMP) to form thymidine monophosphate (dTMP). Administration of 5-FU causes a scarcity in dTMP, so rapidly dividing cancerous cells undergo cell death via thymineless death. Calcium folinate provides an exogenous source of reduced folinates and hence stabilise the 5-FU-TS complex hence enhancing 5-FU's cytotoxicity.


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Company Info

MOSINTER GROUP LIMITED [China (Mainland)]

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Business Type:Manufacturer, Trading Company
City: Ningbo
Province/State: Zhejiang
Country/Region: China (Mainland)

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