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MOSINTER GROUP LIMITED
MOSINTER GROUP LIMITED

China Linifanib CAS 796967-16-3 ABT-869 manufacturer

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Linifanib CAS 796967-16-3 ABT-869 

Payment Terms: T/T,L/C,WU 
Place of Origin: Shandong, China (Mainland) 
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Product Detail

Model No.: C21H18FN5O
Production Capacity: 5 KG/YEAR
Delivery Date: within 7 days
Molecular Formula: C21H18FN5O
Specification: CP/USP/EP
Boiling point: 542.203°C at 760 mmHg
Content: 98%min
Storage condition: -20°C Freezer
Means of Transport: Ocean,Land,Air
Packing: As per request of clients
Brand: MOSINTER
Molecular Weight: 375.405
Melting Point: 180-183°C (dec.)
Density: 1.424
Flashing point: 281.715°C

Linifanib (ABT-869) is a structurally novel, potent inhibitor of receptor tyrosine kinases (RTK)

ABT-869 ( Linifanib ) ( CAS: 796967-16-3 )


Item

Index

Molecular Formula

C21H18FN5O

Molecular Weight

375.405

Specification

CP/USP/EP

Content

98%min

Linifanib (ABT-869) is a structurally novel, potent inhibitor of receptor tyrosine kinases (RTK), vascular endothelial growth factor (VEGF) andplatelet-derived growth factor (PDGF) with IC50 of 0.2, 2, 4, and 7 nM for human endothelial cells, PDGF receptor beta (PDGFR-β), KDR, and colony stimulating factor 1 receptor (CSF-1R), respectively. It has much less activity (IC50s > 1 μM) against unrelated RTKs, soluble tyrosine kinases, or serine/threonine kinases. In vivo linifanib is effective orally in mechanism-based murine models of VEGF-induced uterine edema (ED50 = 0.5 mg/kg) and corneal angiogenesis (>50%inhibition, 15 mg/kg).

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Company Info

MOSINTER GROUP LIMITED [China (Mainland)]

sgs ico Offline Showroom in USA

Business Type:Manufacturer, Trading Company
City: Ningbo
Province/State: Zhejiang
Country/Region: China (Mainland)

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