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MOSINTER GROUP LIMITED
MOSINTER GROUP LIMITED

China Nilotinib CAS 641571-10-0 AMN 107 Tasigna manufacturer

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Nilotinib CAS 641571-10-0 AMN 107 Tasigna 

Payment Terms: T/T,L/C,WU 
Place of Origin: Shandong, China (Mainland) 
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Product Detail

Model No.: C28H22F3N7O
Production Capacity: 50 Klogram/Year
Delivery Date: within 7 days
Molecular Formula: C28H22F3N7O
Molecular Weight: 529.52
Specification: CP/USP/EP
Means of Transport: Ocean,Land,Air
Packing: According to the request of...
Brand: MOSINTER
Content: 99%
Density: 1.362g/cm3

The use of low doses of nilotinib is being investigated for use for Parkinson's and Alzheimer's disease, as well as for ALS, dementia and Huntington's

Nilotinib(CAS: 641571-10-0)

Item

Index

Molecular Formula

C28H22F3N7O

Molecular Weight

529.52

Specification

CP/USP/EP

Content

99%

Nilotinib (AMN107, trade name Tasigna), in the form of the hydrochloride monohydrate salt, is a small molecule tyrosine kinase inhibitorapproved for the treatment of imatinib-resistant chronic myelogenous leukemia.

Medical uses

It is FDA- (29 October 2007), EMA- (29 September 2009), MHRA- (19 November 2007) and TGA- (17 January 2008) approved for use as a treatment for Philadelphia Chromosome (Ph+)-positive Chronic myelogenous leukaemia. In June 2006, a Phase I clinical trial found nilotinib has a relatively favorable safety profile and shows activity in cases of CML resistant to treatment with imatinib, another tyrosine kinase inhibitor currently used as a first-line treatment. In that study 92% of patients (already resistant or unresponsive to imatinib) achieved a normal white blood cell counts after five months of treatment. The drug carries a black box warning for possible heart complications. The use of low doses of nilotinib is being investigated for use for Parkinson's and Alzheimer's disease, as well as for ALS, dementia and Huntington's disease. Novartis announced on April 11, 2011 that it is discontinuing a Phase III trial of Tasigna® (nilotinib) for investigational use in the first-line treatment of gastrointestinal stromal tumor (GIST) based on the recommendation of an independent data monitoring committee. Interim results showed Tasigna is unlikely to demonstrate superiority compared to Novartis's Glivec® (imatinib)*, the current standard of care in this setting.

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Company Info

MOSINTER GROUP LIMITED [China (Mainland)]

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Business Type:Manufacturer, Trading Company
City: Ningbo
Province/State: Zhejiang
Country/Region: China (Mainland)

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