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MOSINTER GROUP LIMITED
MOSINTER GROUP LIMITED

China Capecitabine CAS 154361-50-9 Xeloda Ro091978 R340 manufacturer

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Capecitabine CAS 154361-50-9 Xeloda Ro091978 R340 

Payment Terms: T/T,WU 
Place of Origin: Shandong, China (Mainland) 
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Product Detail

Means of Transport: Ocean,Land,Air
Packing: According to the request of...
Brand Name: MOSINTER
Purity: 99% MIN
Molecular weight: 245.2077
Boiling point: 437.874°C at 760 mmHg
Storage condition: -20°C Freezer
Production Capacity: 10 Ton/year
Delivery Date: with in 7 days
CAS No.: 154361-50-9
Molecular formula: C9H12FN3O4
Density: 1.841g/cm3
Flashing point: 218.619°C
Alias: Xeloda

Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of numerous cancers.

Capecitabine (CAS: 154361-50-9)


Contents

Specification

Results

Characters

White or almost white powder

White powder

Solubility

    Freely soluble in methanol;soluble in   acetonitrile and in alcohol;sparingly soluble in water

Conforms

Identification

A:Infrared Absorption

Conforms

B:the retention time of the major peak in   the chromatogram of the Assay preparation corresponds to that in the   chromatogram of the Standard preparation,as obtained in the Assay

Conforms

Water

Not more than 0.3%

0.05%

Specific rotation

+96.0°~   100.0°

+96.8°

Residue on ignition

≤   0.1%

0.03%

Heavy metals

Not more than 20ppm

Conforms

Related compounds

Capecitabine related compound A≤0.3%

0.001%

Capecitabine related compound B≤0.3%

N.D.

2',3'-Di-O-acetyl-5'-deoxy-5-fluorocytidine≤0.1%

N.D.

5'-Deoxy-5-fluoro-N4-(2-methyl-1-butyloxycarbonyl)

cytidine+5'-Deoxy-5-fluoro-N4-(3-methyl-1-butyloxy

carbonyl) cytidine≤0.5%

0.004%

[1-[5-Deoxy-3-O-(5-β-D-ribofuranosyl)- β-D-ribofuranosyl]-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]-carbamic   acid pentyl

ester≤0.3%

N.D.

[1-[5-Deoxy-2-O-(5-β-D-ribofuranosyl)- β-D-ribofuranosyl]-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]-carbamic   acid pentyl

ester≤0.2%

N.D.

Capecitabine related compound C≤0.2%

0.02%

[1-[5-Deoxy-2-O-(5-α-D-ribofuranosyl)- β-D-ribofuranosyl]-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]-carbamic   acid pentyl este≤0.3%

0.01%.

2',3'-Di-O-acetyl-5'-deoxy-5-fluoro-N4-(pentyloxycarbonyl)   Cytidine≤0.1%

N.D.

Individual   unspecified impurity≤0.1%

0.02%

Total   unspecified impurities≤0.5%

0.04%

Total   impurities≤1.5%

0.08%

Residual solvent

Ethyl   Acetate  ≤5000ppm

20ppm

Methanol  ≤3000ppm

200ppm

Ethanol   ≤5000ppm

1ppm

Pyridine   ≤200ppm

7ppm

Hexane ≤290ppm

6ppm

Dichloromethane   ≤600ppm

40 ppm

Toluene   ≤890ppm 

3ppm

Assay

98%-102.0%

 (Calculated on the anhydrous and   solvent-free basis)

99.8%

Conclusion: It complies with the   requirements of the USP34


Related Information:

Melting point:110-121 ℃

Loss on drying:≤1.0%

Application:

Mainly used for primary or metastatic breast cancer, rectal cancer, colon cancer and stomach cancer treatment.

It is used in the treatment of the following cancers:

  • Colorectal cancer (either adjuvant therapy or for metastatic cases)

  • Breast cancer (metastatic or as monotherapy/combotherapy; this is licensed as a second-line treatment in the UK)

  • Gastric cancer (off-label in the US; this is a licensed indication in the UK)

  • Oesophageal cancer (off-label in the US)

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Company Info

MOSINTER GROUP LIMITED [China (Mainland)]

sgs ico Offline Showroom in USA

Business Type:Manufacturer, Trading Company
City: Ningbo
Province/State: Zhejiang
Country/Region: China (Mainland)

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